• This study investigates and compares the within and in-between variances of the body responses to different heat stressors in a controlled lab-setting. The participants will be exposed to different heat sources while a variety of physiological heat strain reactions such as heartrate, sweat rate, and core body temperature are recorded using on- and in-body devices. For the participant monitoring during the study, medical grade devices such as a certified ECG and a swallowable sensor-pill to continuously monitor the core body temperature will be applied. A one-for-all wearable device is additionally applied for physiological validation. Further, sweat will be collected to assess (i) the local sweat rate and (ii) the appearance of different heat stress associated molecular markers in this non-invasively collectable biofluid. As a secondary aim, a model will be developed that will enable to predict the different heat stress sources out of the heat strain measurements.
Study Type
OBSERVATIONAL
Enrollment
23
Temporary exposure to increased ambient temperature +10°C (the effect of the intervention is fully and spontaneously reversible)
Temporary exposure to increased ambient relative humidity +40% (max. 90%) (the effect of the intervention is fully and spontaneously reversible)
Temporary exertion on an ergometer (1W/kg body weight) (the effect of the intervention is fully and spontaneously reversible)
ETH Zurich
Zurich, Andere (Nicht USA-Länder), Switzerland
The within and between subject heat strain marker variability in relation to specific heat stress sources (ambient heat, ambient humidity, exertion, and clothing)
The primary endpoint is the within- and between- subject heat strain marker variability of HR, CBT, WSR, and LSR in relation to various heat stress sources (increased ambient temperature, increased relative humidity, and exertion, all without and with additional clothing.
Time frame: Max. 7 days
Accuracy to detect the specific heat stress source (such as ambient heat, relative humidity) from different on- and in-body measurements
The models for the primary endpoints will be extended to explore the relationships between heat strain parameters, heat stress sources, as well as personal characteristics. Additionally, prediction of heat stress source will be explored.
Time frame: Max. 7 days
Assessment of short-term heart rate variability in context to each heat stressor.
Short-term HRV with a repeating time frame of 5min. Root mean square of successive RR interval (RMSSD; in \[ms\]) and the Standard-deviation of RR intervals (SDRR; in \[ms\]) will be computed with respect to each heat stress source.
Time frame: Max. 7 days
Temperature [°C] and relative humidity [%] of the microenvironment as an additional source of information for patterns to detect heat stressors
Features of temperature \[°C\] and relative humidity \[%\] of the microenvironment as additional model predictors.
Time frame: Max. 7 days
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