Clinical Trial of Recombinant Pneumococcal Protein Vaccine

Inclusion Criteria: * Adults 50 years and older at the time of screening * Willingness to provide legal proof of identity * Ability to understand the clinical study and voluntarily sign an informed consent form and complete a 6-month follow-up * Ability to comply with the requirements of the clinical research protocol Exclusion Criteria: * Fever, axillary body temperature \>37.0℃ before vaccination * Positive human immunodeficiency virus (HIV) screening * History of epilepsy, convulsions or seizures or a history of psychiatric illness or family history * Received immunosuppressive therapy, cytotoxic therapy, glucocorticoid therapy (excluding topical therapy, surface therapy for acute uncomplicated dermatitis, spray therapy for allergic rhinitis) within the past 6 months (interval \<6 months) * Suffering from serious chronic diseases or conditions in progress that can't be controlled smoothly, such as serious cardiovascular diseases, chronic hemolytic anemia, thyroid diseases, etc. (except thyroid nodules) * History of severe anaphylactic reactions (e.g., systemic allergic reactions) to any component of the test drug and/or history of serious adverse reactions associated with other vaccines, such as allergy, urticaria, dyspnea, angioneurotic edema, or abdominal pain * People with hypertension that cannot be controlled by medication (when measured on site: systolic blood pressure ≥ 160 mmHg, diastolic blood pressure is ≥ 100 mmHg) * Pre-immune hemoglobin, white blood cell count, alanine aminotransferase, aspartate aminotransferase, total bilirubin, creatine phosphokinase (CPK), and troponin (CTN) test results are abnormal and are judged by the investigator to be clinically significant * Positive urine pregnancy test or lactating women, volunteers or their partners planning to become pregnant * Diseases caused by Streptococcus pneumoniae such as pneumococcal pneumonia, pneumococcal meningitis, etc. within the last 5 years * Allergic persons, such as those who are allergic to two or more drugs or foods or those who are severely allergic to one drug or food * Immunocompromised individuals with known or suspected congenital/acquired immunodeficiency as determined by medical history and/or physical examination, uncontrolled autoimmune diseases, etc * Abnormal coagulation (e.g., clotting factor deficiency, coagulopathy, platelet abnormalities) or significant bruising or clotting disorders * No spleen or splenectomy due to any condition * Acute attack of various acute or chronic diseases within the last 7 days * Pneumococcal vaccination within the last 5 years * Received or planned to receive blood/plasma products or immunoglobulins during the study period or 3 months prior to vaccination * Received or plan to participate in an interventional study, receive another investigational drug, vaccine or treatment during the study within the last 1 month * Received live attenuated vaccine within the last 14 days * Received subunit vaccine or inactivated vaccine within the last 7 days * Those planning to have surgery during the study period * Subject has any other factors that, in the judgment of the investigator, make them unsuitable for participation in the clinical trial