The Impact of Oligo-Fucoidan in Cancer Cachexia and Sarcopenia

Inclusion Criteria: 1. Histologically confirmed patients with stage III-IV non-small cell lung cancer, colorectal carcinoma, head and neck cancer, nasopharyngeal cancer, or pancreatic carcinoma, who are not eligible for surgery, and interventional treatment . 2. Chemotherapy regimen include platinum-based drugs and Gemcitabine based drugs; 3. For patients who are being treated with chemotherapy, the chemotherapy regimen should be confined to the regimens specified in the protocol; and the chemotherapy regimen, in general, are not allowed to be changed during the study period; 4. Patients are conscious and able to cooperate with the doctor to complete the disease-related examinations and evaluations; 5. ECOG performance status (PS) 0-3 for those who are not treated with chemotherapy; and ECOG PS 0-2 for those who are being treated with chemotherapy; 6. Expected survival period is more than 3 months; 7. Male or female aged 20 - 90 years; 8. Patients who are willing to participate in the study and sign the informed consent form. Exclusion Criteria: 1. Patients who are being treated with chemotherapy, the chemotherapy regimen is not among the regimens specified in the protocol; 2. Patients with cachexia caused by other reasons, e.g. severe hepatic dysfunction \[Aspartate transaminase(AST)/Cerealthirdtransaminase(ALT) \>5 times the ULN\], severe renal dysfunction (Cr \>1.5 times the ULN), uncontrolled thyroid disease, New York Heart Association (NYHA) class III-IV heart failure, AIDS etc.; 3. Any condition that may hinder the subject's completion of the study, including but not limited to severe uncontrollable organic diseases or infection, unstable angina pectoris, congestive heart failure, etc.; 4. Known or suspected diagnosis of metastatic encephaloma; 5. Patients present with an ECOG score\>2 and require treatment of chemotherapy; 6. Patients who are currently included in other clinical trials on antineoplastic drugs; 7. Patients who are not able to provide the Informed Consent Form (ICF); 8. Expected survival period is less than 4 months; 9. Female patient is pregnant or breast-feeding, and those patients at childbearing age who are not willing to use methods of contraception (including males); 10. Patients with symptomatic, uncontrolled nervous disorders, mental illness or psychiatric disorder; 11. Any condition, in the investigator's opinion, is not in the best interest of the subject (e.g., harming the subject's health) or potentially interferes with the evaluation of treatment according to this protocol.