Consumers are increasingly encouraged to consume more plant-based foods and lower their consumption of foods from animal origin. However, the consequences of such a transition on muscle mass still remains to be explored. This is of particular importance in the older population, where sarcopenia is highly prevalent. The aim of this randomized controlled cross-over study is to investigate the short-term effect of a 10-day controlled vegan diet on daily muscle fractional synthesis rates in comparison to a 10-day controlled omnivorous diet in 35 community-dwelling older adults. Participants will follow a fully controlled vegan diet, directly followed by a fully controlled omnivorous diet for 10 days, or vice versa. Researchers will compare the effect of the vegan diet to the effect of the omnivorous diet.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
38
The intervention diet will be a fully controlled vegan diet that will be consumed for a duration of 10 days. No animal-based food products will be included in the diet.
The control diet will be an a priori composed controlled omnivorous diet with a duration of 10 days. The omnivorous diet and the vegan diet will be isocaloric and isonitrogenous.
Wageningen University and Research
Wageningen, Gelderland, Netherlands
Muscle Protein Synthesis (MPS)
MPS, expressed as daily fractional synthesis rates (FSR, %/day), will be assessed using a deuterium oxide protocol. Daily FSR will be calculated using the 2\^H-alanine enrichment in plasma and the mixed muscle-bound 2\^H-alanine enrichment.
Time frame: 10 days
Appetite
Appetite will be assessed using visual analogue scales (VAS; Min 0 mm - max 100 mm) before and after the warm meal. Five VAS-scales regarding hunger, fullness, satiation, desire to eat and prospective food consumption will be used to assess appetite.
Time frame: Measured daily for 10 days during each diet
Change in fasting plasma glucose
Fasting plasma glucose levels
Time frame: Change after 10 days of following each diet
Change in fasting plasma insulin
Fasting plasma insulin levels
Time frame: Change after 10 days of following each diet
Change in fasting plasma lipid profile
Triglycerides, high-density lipoprotein-cholesterol, low-density lipoprotein cholesterol, total cholesterol
Time frame: Change after 10 days of following each diet
Change in blood pressure
Fasting systolic and diastolic blood pressure
Time frame: Change after 10 days of following each diet
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