The patients with Omicron infection usually have fever, respiratory symptoms, tachycardia, headache, toothache, muscle soreness, physical decline, and so on, while others are asymptomatic patients. It is urgent to find drugs to improve the long-term rehabilitation of symptomatic patients with Omicron infection and decrease the duration of viral shedding in both symptomatic and asymptomatic patients. This study aims to investigate the efficacy and safety of Lianhua Qingke tablets in patients with Omicron infection. The duration of viral shedding and symptoms will be evaluated. 6-month follow-up will be performed to evaluate the effect of Lianhua Qingke on long-term rehabilitation of all symptoms induced by Omicron infection, as well as infection events.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
2,000
Lianhua Qingke tablets: 4 tablets once, three times daily
International Convention and Exhibition Center Shelter Hospital
Ürümqi, Xinjiang, China
RECRUITINGIncidence of all Infection events
Recurrence coronavirus infection or any new infection events
Time frame: From discharge to 6 months
Duration of viral shedding
Nucleic acid negative conversion time before discharge
Time frame: 6 months
Negative conversion ratio
Nucleic acid negative conversion ratio
Time frame: 7 days
Positive conversion ratio
Nucleic acid positive conversion ratio
Time frame: From discharge to 6 months
Duration of main symptoms before discharge
Time frame: 6 months
Disappearance ratio of main symptoms
Time frame: 7 days
Recurrence frequency of main clinical symptoms
Time frame: From discharge to 6 months
Mean duration of main clinical symptoms
Time frame: From discharge to 6 months
Frequency of fever
Time frame: From discharge to 6 months
Mean duration of fever
Time frame: From discharge to 6 months
Duration of fever before discharge
Time frame: 6 months
Disappearance ratio of fever
Time frame: 7 days
Frequency of respiratory symptoms
Time frame: From discharge to 6 months
Mean duration of respiratory symptoms
Time frame: From discharge to 6 months
Duration of respiratory symptoms before discharge
Time frame: 6 months
Disappearance ratio of respiratory symptoms
Time frame: 7 days
Frequency of nasal congestion or runny nose
Time frame: From discharge to 6 months
Mean duration of nasal congestion or runny nose
Time frame: From discharge to 6 months
Duration of nasal congestion or runny nose before discharge
Time frame: 6 months
Disappearance ratio of nasal congestion or runny nose
Time frame: 7 days
Frequency of chest distress
Time frame: From discharge to 6 months
Mean duration of chest distress
Time frame: From discharge to 6 months
Duration of chest distress before discharge
Time frame: 6 months
Disappearance ratio of chest distress
Time frame: 7 days
Frequency of palpitations
Time frame: From discharge to 6 months
Mean duration of palpitations
Time frame: From discharge to 6 months
Duration of palpitations before discharge
Time frame: 6 months
Disappearance ratio of palpitations
Time frame: 7 days
Frequency of pharyngeal discomfort
Time frame: From discharge to 6 months
Mean duration of pharyngeal discomfort
Time frame: From discharge to 6 months
Duration of pharyngeal discomfort before discharge
Time frame: 6 months
Disappearance ratio of pharyngeal discomfort
Time frame: 7 days
Frequency of headache
Time frame: From discharge to 6 months
Mean duration of headache
Time frame: From discharge to 6 months
Duration of headache before discharge
Time frame: 6 months
Disappearance ratio of headache
Time frame: 7 days
Frequency of dizziness
Time frame: From discharge to 6 months
Mean duration of dizziness
Time frame: From discharge to 6 months
Duration of dizziness before discharge
Time frame: 6 months
Disappearance ratio of dizziness
Time frame: 7 days
Frequency of toothache
Time frame: From discharge to 6 months
Mean duration of toothache
Time frame: From discharge to 6 months
Duration of toothache before discharge
Time frame: 6 months
Disappearance ratio of toothache
Time frame: 7 days
Frequency of muscle soreness
Time frame: From discharge to 6 months
Mean duration of muscle soreness
Time frame: From discharge to 6 months
Duration of muscle soreness before discharge
Time frame: 6 months
Disappearance ratio of muscle soreness
Time frame: 7 days
Frequency of physical decline
Time frame: From discharge to 6 months
Mean duration of physical decline
Time frame: From discharge to 6 months
Duration of physical decline before discharge
Time frame: 6 months
Disappearance ratio of physical decline
Time frame: 7 days
Frequency of gastrointestinal symptoms
Time frame: From discharge to 6 months
Mean duration of gastrointestinal symptoms
Time frame: From discharge to 6 months
Duration of gastrointestinal symptoms before discharge
Time frame: 6 months
Disappearance ratio of gastrointestinal symptoms
Time frame: 7 days
Frequency of urinary symptoms
Time frame: From discharge to 6 months
Mean duration of urinary symptoms
Time frame: From discharge to 6 months
Duration of urinary symptoms before discharge
Time frame: 6 months
Disappearance ratio of urinary symptoms
Time frame: 7 days
Infection events except SARS-CoV-2
Time frame: From discharge to 6 months
Heart rates
Time frame: 6 months
Heart rates
Time frame: Baseline
Heart rates
Time frame: 7 days
Blood pressure
both systolic and diastolic blood pressure
Time frame: 6 months
Blood pressure
both systolic and diastolic blood pressure
Time frame: Baseline
Blood pressure
both systolic and diastolic blood pressure
Time frame: 7 days
Incidence of drug-related adverse events
Time frame: 7 days
Incidence of drug-related adverse events
Time frame: 6 months
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