Patients With and Without Phonotrauma

University of Texas Southwestern Medical Center100 enrolled

Overview

There is a substantial need to identify objective measures associated with hyperadduction of the vocal folds to recognize those at higher risk of developing phonotrauma so that risk mitigation strategies can be implemented before phonotrauma develops. The overall objective of this proposed project is to investigate the sensitivity and direction of change in cepstral peak prominence (CPP) and the magnitude difference between the first two harmonics of the voice spectrum (H1-H2) in response to varied phonation patterns, which will be addressed using the following two aims: Aim 1: Determine how CPP and H1-H2 change as a function of using pressed voice production in individuals without laryngeal pathology. Aim 2: Examine the sensitivity (minimally detectable change) and responsiveness (minimal clinically important difference) of CPP and H1-H2 to detect changes in different voice production conditions.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Phonotrauma

Interventions

Acoustic voice analysisDIAGNOSTIC_TEST

Acoustic recordings will involve the five repetitions of three vowels (/ɑ, i, u/) and a standard reading passage (Rainbow Passage) in different voice conditions. Control participants will produce voice in breathy, typical, and pressed conditions. Patient participants will produce voice in typical production and in a resonant voice production. High-speed videoendoscopy and simultaneous acoustic recording will occur on one repetition of a sustained /i/ in each requested condition. Data will be collected using a head-mounted microphone.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Control Group: Inclusion Criteria: 1. 18-65 years of age (to avoid confounding physiological factors related to puberty or presbyphonia) 2. No history of or current voice disorder 3. Auditory perceptual presentation globally within functional limits (as determined by a voice specialized SLP). Exclusion Criteria: 1. Atypical auditory-perceptual voice presentation 2. History of voice disorder or laryngeal surgery. Patient Group: Inclusion Criteria: 1. Diagnosed with phonotrauma (i.e., vocal fold nodules, vocal fold polyp, vocal fold pseudocyst, mid-fold edema) by a laryngologist. 2. 18-65 years of age Exclusion Criteria: 1. Diagnosis of voice disorder not related to phonotrauma (e.g., vocal fold immobility, laryngeal dystonia, primary muscle tension dysphonia, etc.) 2. Previous history of laryngeal surgery or voice therapy (to avoid confounding effects of previous treatment).

Outcomes

Primary Outcomes

Cepstral Peak Prominence

Cepstral peak prominence is a measure of the periodic energy of the acoustic voice signal.

Time frame: 1 year

The difference between the first and second harmonic (H1-H2)

H1-H2 is a spectral measure derived from the acoustic voice signal that correlates with glottal configuration.

Time frame: 1 year

Average closing velocity

Vocal fold closing phase velocity averaged across 100 vibratory cycles

Time frame: 1 year

Patients With and Without Phonotrauma

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Central Contacts