Graves' orbitopathy (GO) is an disfiguring and disabling autoimmune condition. Sight-threatening GO is an most severe form and occurs in about 5% of patients with Graves' disease. It can cause blurred vision, color vision and vision function damage, and affects the quality of life. The goal of this retrospective cohort study is to propose a customized orbital decompression algorithm for patients with sight-threatening Graves'ophthalmopathy and to explore the therapeutic effect of customized orbital decompression in sight-threatening patients.
Study Type
OBSERVATIONAL
Enrollment
78
Thyroid dysfunction of all patients is stabilized by ATDs until treatment of TAO is completed. All patients with sight-threatening GO were admitted for emergency steroid pulse therapy. And additional drugs for protecting gastrointestinal mucous membrane, potassium and calcium supplements, and sedatives were used. All emergency cases, whose signs of visual impairment clinically attributable to GO existed despite first-line steroid treatment, were referred and discussed at the surgical board of our interdisciplinary center for prompt surgical orbital decompression. Urgent orbital decompression was performed when response is absent or poor within 1-2 weeks.
Sun Yat-sen Memorial Hospital
Guangzhou, Guangdong, China
RECRUITINGBCVA
best corrected visual acuity in logMAR
Time frame: 12 months
CAS
clinical activity score
Time frame: 12 months
proptosis
proptosis in mm
Time frame: 12 months
EVP
Visual Evoked Potential
Time frame: 12 months
GO-QOL
Graves' Ophthalmopathy Quality of Life
Time frame: 12 months
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