Optimization Strategy of Carotid Artery Stenosis

Peking Union Medical College Hospital1,000 enrolled

Overview

The goal of this observational study is to learn about how to utilize multiple evaluation techniques in carotid artery stenosis patients for optimizing assessment of diagnosis and treatment strategy. The main questions it aims to answer are: * Identify best strategy that use multi-modal MRI and CT to assess patients' cerebral lesions and perfusion. * Identify best strategy that use multi-modal MRI, PET-MRI ultrasound and CT to assess components and characters of patients' carotid plaques. Participants will accept imaging examination before and after surgery. And doctors will collect basic characteristics, imaging results and biological samples of patients for analysis.

Study Type

OBSERVATIONAL

Enrollment

1,000

Conditions

Carotid Artery Stenosis

Interventions

Carotid revascularizationPROCEDURE

All patients received carotid revascularization surgery at Peking Union Medical College Hospital.

Multi-modal MRI before and after surgery.

CTADIAGNOSTIC_TEST

CTA before and after surgery.

PET/MRIDIAGNOSTIC_TEST

PET/MRI before surgery.

UltrasoundDIAGNOSTIC_TEST

Ultrasound before and after surgery.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. patients with severe stenosis (≥50%) or near-occlusion diagnosed by computed tomographic angiogram; 2. patients received carotid endarterectomy at Peking Union Medical College Hospital Exclusion Criteria: (1) Any contraindication to image examination; (3) refuse to sign the Informed consent.

Locations (1)

vascular surgery department of PUMCH

Beijing, Beijing Municipality, China

RECRUITING