Prediction of Long-term Outcome in Aortic Stenosis After Valve Intervention

Uppsala University300 enrolled

Overview

Patients with severe aortic stenosis accepted for transcatheter intervention or open surgery are included before the intervention, and then followed up with clinical visits during the first year after intervention. Imaging with echocardiography and computed tomography (CT) are performed together with additional imaging with magnetic resonance imaging (MRI) and Positron emissions tomography (PET)-CT in a subgroup of the study population. Blood samples, physical performance and questionnaires with focus on frailty and heart failure are also collected at each visit. A follow up with information of the outcomes after 2-5 years will be performed through national registries.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Aortic Stenosis

Interventions

There is no intervention since it is an observational study patients are treated according to clinical praxisOTHER

No intervention

Outcomes

Primary Outcomes

Semiquantitative assessment of protein levels associated with myocardial performance

Level of normalized protein expression (NPX) in plasma, assessed by a multiplex proximity extension assay panel (Olink Bioscience, Uppsala, Sweden).

Time frame: One year after intervention.

Imaging parameters associated with clinical outcome after intervention

Global longitudinal strain (%) of the right and left ventricle. The clinical outcome defined as a combination of mortality and hospitalization of heart failure

Time frame: One year after intervention

Semiquantitative assessment of protein levels associated with myocardial performance associated with clinical outcome after intervention

Level of normalized protein expression (NPX) in plasma, assessed by a multiplex proximity extension assay panel (Olink Bioscience, Uppsala, Sweden). The clinical outcome defined as a combination of mortality and hospitalization for heart failure.

Time frame: Two years after intervention

Secondary Outcomes

Imaging parameters associated with clinical outcome after intervention

Volumes of the right and left ventricle (mL/m2). The clinical outcome defined as a combination of mortality and hospitalization for heart failure.