the early application of non-invasive PNS in MV patients can increase the number of days without mechanical ventilation, delay disuse phrenic atrophy, and improve the strength of inspiratory muscle.
A prospective randomized controlled study included 104 patients with MV who met inclusion criteria in multiple hospital ICU units and were randomly divided 1:1 into PNS and conventional groups. The PNS group received neuromuscular electrical stimulation in addition to routine airway management, early activity and respiratory muscle training. It was verified that early non-invasive PNS could increase the number of days without mechanical ventilation for 28 days, delay disused diaphragm atrophy and improve inspiratory muscle strength.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
104
Some studies have shown that PNS can relieve diaphragmatic atrophy and reverse diaphragmatic dysfunction.
Bing Sun
Beijing, Beijing Municipality, China
RECRUITINGVentilator-free days
Time frame: 28 days
mechanical ventilation days
Time frame: 28 days
re-intubation rate
Time frame: 28 days
ICU mortality
Time frame: 28 days
60/90-day survival rate
Time frame: 28 days
Maximal Inspiratory Pressure
Time frame: up to 28 days
Diaphragm thickness
Time frame: up to 28 days
diaphragm thickening fraction
Time frame: up to 28 days
Transdiaphragmatic Pressure
Time frame: up to 28 days
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