Transpulmonary Pressure in Right Ventricle Protection of ARDS

Beijing Chao Yang Hospital40 enrolled

Overview

To compare the effect between mechanical ventilation strategy guided by transpulmonary pressure and tranditional lung protective ventilation strategy in acute respiratory distress syndrome for right ventricle protection.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Acute Respiratory Distress Syndrome Acute Cor Pulmonale

Interventions

mechanical ventilation strategy guided by transpulmonary pressurePROCEDURE

Mechanical ventilation parameters adjust guided by transpulmonary pressure monitoring. For pressure assist control or volumn assit control mode; inspiratory pressure or volumn setting needs to maintain Ppeak less than 25 cm H2O; PEEP was set at such a level that expiratory Ptp stayed between 0 and 5 cm H2O.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * duration of invasive mechanical ventilation less than 72 hours; * meet the diagnostic criteria of Berlin definition for ARDS; * age older than 18 Exclusion Criteria: * esophageal surgery or damage; * cardiac surgery; * severe bronchopleural fistula; * serious arrhythmia; pneumothorax; * tricuspid stenosis; * heparin allergy; * chronic pulmonary heart disease

Locations (1)

Beijing Chao-Yang Hospital

Beijing, Beijing Municipality, China

RECRUITING

Outcomes

Primary Outcomes

Pulmonary vascular resistance (PVR)

PVR will measured by Swan-Ganz catheter

Time frame: 3 days

Pulmonary vascular compliance

Pulmonary vascular compliance will be calculated using pulmonary artery pressure divided by stroke output measured by Swan-Ganz catheter.

Time frame: 3 days

Central Contacts

Xiao Tang, MD

CONTACT

+86013811089795 tangxiao0928@163.com

Data from ClinicalTrials.gov

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