Efficacy of Dengue Infection With Warning Signs Treated With Dexamethasone (DengDex Study)

Chulalongkorn University200 enrolled

Overview

The goal of this randomized double-blinded placebo-controlled trial is to learn about dexamethasone and the treatment of severe dengue population. The main question it aims to answer are steroid therapy may be effective in dengue.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

200

Conditions

Severe Dengue

Interventions

DexamethasoneDRUG

Patients treated with dexamethasone

PlaceboDRUG

Patients treated with placebo

Eligibility

Sex: ALLMin age: 7 YearsMax age: 99 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Laboratory confirmed Dengue infected patients (Positive NS1 Ag or anti-DENV IgM by Dengue Duo test) * And still in febrile phase (Body temp\>37.5 C) * Shock : Sys\<90mmHg or Narrow PP (\<20mmHg) orTachycardia (pulse\>100/min) with Hematocrit decreased ≥20 % * Fluid accumulation and respiratory distress * Severe bleeding * Severe organ involvement Exclusion Criteria: * Severe dengue\> 24 hrs * Dengue without warning signs * Pregnancy * Patient who receieved any steroid within 1 week

Locations (2)

Chulalongkorn University

Bangkok, Thailand

RECRUITING

King Chulalongkorn Memorial Hospital

Bangkok, Thailand

RECRUITING

Outcomes

Primary Outcomes

Mortality

The use of steroids in dengue will reduce mortality in rate

Time frame: 28 days

Secondary Outcomes

Length of hospital stay

The use of steroids in dengue will reduce Length of hospital stay in day

Time frame: 28 days

Data from ClinicalTrials.gov

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