Bone Marrow Mononuclear Cells vs Mesenchymal Stem Cells in Diabetic Patients With Chronic Limb Ischemia

Inclusion Criteria: * Adult male or female, 40 years of age or over (until 85 years old) * TcPO2 ≤ 30 mmHg. * Diagnosis of diabetes. * Patients with signs of critical ischemia such as (i) ulcer that does not heal, (ii) necrosis or loss of tissue, (iii) pain at rest, and (iv) intermittent claudication. * Basal Rutherford classification stage 3 to 5. * Non-revascularizable patients due to comorbidities and/or anatomy. * Patients that despite revascularization (vascular surgery), have adequate distal beds to perfuse the limb. * Ankle/brachial index less than 0.4. * Stenosis or occlusion of the infrapatellar arteries. Exclusion Criteria: * Participants that do not sign the informed consent. * Presence of osteomyelitis. * Hemodynamic instability (MAP\<65 mmHg or vasopressor requirement). * Any acute systemic infectious disease process. * Severe sepsis. * Uncontrolled coagulopathy. * Condition of cancer. * Use of immunosuppressive or cytotoxic drugs * Alterations of the bone marrow that do not allow the adequate extraction of the components to be used as: acute leukemia, chronic leukemia, marrow aplasia, myelodysplastic syndrome, and myelophthisis. * Contraindication of sedation for bone marrow aspirate. * Patients who have suffered in a period \< six months of myocardial infarction, disease cerebrovascular or coronary intervention. * Patients with liver failure indicated by serum transaminases (aspartate aminotransferase and alanine aminotransferase), with values twice the normal limit. * Any acute or chronic contagious disease including hepatitis B, hepatitis C, and HIV. * Any other comorbidity that the treating vascular surgeon considers as a contraindication to cell treatments.