COlombia DAISe FEasibility Exercise

Inclusion Criteria: * Age 18 years or older. * Pre-stroke (24 hours prior to stroke onset) independent functional status in activities of daily living with modified Rankin Score 0-2. * Diagnosis of acute ischemic stroke with study enrollment time \< 8 hours from onset of symptoms. * Disabling stroke defined as a baseline NIHSS \> 6. * Confirmed symptomatic, large vessel occlusion of the intracranial internal carotid artery, middle cerebral artery, M1. * Signed informed consent from patient or legal representative. Exclusion Criteria: * Computed tomography (CT) or Magnetic Resonance Imaging (MRI) evidence of recent/ fresh hemorrhage on presentation. * Clinical history, past imaging or clinical judgment suggests that the intracranial occlusion is chronic. * Rapidly improving neurological deficits based on the investigator's clinical judgement. * Pregnancy; if a woman is of child-bearing potential and urine or serum beta HCG test is positive. * Severe contrast allergy or absolute contraindication to iodinated contrast. * Difficult endovascular access, difficult aortic arch or severe neurovascular tortuosity that will result in an inability to deliver endovascular therapy. * Evidence of dissection in the carotid or target artery for treatment. * Presence of a carotid artery stenosis or occlusion requiring balloon angioplasty or stenting at time of the procedure. * Renal failure (serum creatinine level ≥ 3 mg/dL or on dialysis). * Severe, sustained hypertension resistant to treatment (SBP \>185 mmHg or DBP\>110 mmHg). * Use of warfarin anticoagulation with International Normalized Ratio (INR) \>3.0 at the time of the procedure or any known hemorrhagic or coagulation deficiency. * Use of a direct thrombin inhibitor within the last 48 hours; partial thromboplastin time (PTT) \> 2.0 times the normal prior to procedure. * Cerebral vasculitis or evidence of active systemic infection. * Suspicion of aortic dissection, presumed septic embolus or suspicion of bacterial endocarditis. * Clinical symptoms suggestive of bilateral stroke or occlusions in multiple vascular territories (e.g., bilateral anterior circulation, or anterior/posterior circulation). * A severe or fatal comorbid illness that will prevent improvement or follow-up or that will render the procedure unlikely to benefit the patient.