The Efficacy and Safety of Fruquintinib Plus FOLFIRI/FOLFOX as Second-line Treatment in Patients With RAS-mutant Metastatic Colorectal Cancer

Inclusion Criteria: * ≥18 years * Histological or cytological confirmed colorectal cancer; * RAS mutation * Expected survival \>12 weeks; * Fail in previous standard therapy, which must include FOLFOX/FOLFIRI; * ECOG PS 0-1; * At least one measurable lesion (according to RECIST1.1); * Adequate hepatic, renal, heart, and hematologic functions; * Negative serum pregnancy test at screening for women of childbearing potential. Exclusion Criteria: * Received other investigational drugs within 4 weeks prior to treatment; * Prior treatment with anti-angiogenic small molecule targeted drugs, such as fruquintinib, etc; * Symptomatic brain or meningeal metastases (except for patients with BMS who have received local radiotherapy or surgery for more than 6 months and whose disease is stable); * Severe infection (e.g., requiring intravenous antibiotics, antifungal drugs, or antiviral drugs) within 4 weeks prior to treatment; * Patients with hypertension that cannot be well controlled by antihypertensive medication (systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg); * Patients who had active bleeding or coagulopathy within 2 months before enrollment, had a tendency to bleed, or were receiving thrombolytic therapy and were considered by the investigator to be ineligible for enrollment; * Active heart disease, including myocardial infarction, severe/unstable angina, 6 months prior to treatment. Echocardiography examination left ventricular ejection fraction \< 50%, arrhythmia control is not good; * The patient has had other malignant tumors within 5 years (except cured basal cell carcinoma of the skin and carcinoma in situ of the cervix); * Allergy to the study drug or any of its excipients; * The patient is unable to take the drug orally, or the patient has a condition judged by the investigator to affect the absorption of the drug; * Women who are pregnant (with a positive pregnancy test before medication) or breastfeeding; * Urine routine showed urine protein ≥2+, and 24-hour urine protein level \>1.0g; * Other conditions deemed by the investigator to be ineligible for inclusion in the study.