Assessment of Cognitive Function and Gut Microbiota Analysis in Real World Patients With Lupus Cerebrovascular Disease

Inclusion Criteria: Retrospective study * Patients enrolled from September 2018 to September 2021 applied for exemption from informed consent, and patients enrolled from September 2021 to September 2022 signed informed consent voluntarily. * Male or female patients aged 14-55 years; * Patients diagnosed with systemic lupus erythematosus are classified according to the European League against Rheumatism (EULAR)/American College of Rheumatology (ACR) joint classification criteria for SLE in 2019. * Cranial imaging examination was performed, and the results of cranial imaging examination were consistent with cerebrovascular disease changes. Prospective Research: SLE group: * The researcher signed the informed consent voluntarily; * Male or female patients aged 14-55 years; * Patients diagnosed with systemic lupus erythematosus are classified according to the European League against Rheumatism (EULAR)/American College of Rheumatology (ACR) joint classification criteria for SLE in 2019. * Patients who need to undergo head imaging examination according to the judgment of treating doctors, and the results of head imaging examination are not consistent with changes in cerebrovascular disease. * No antibiotics have been taken in the past 2 weeks; SLE cerebrovascular disease group * The researcher signed the informed consent voluntarily; * Male or female patients aged 14-55 years * Patients diagnosed with systemic lupus erythematosus are classified according to the European League against Rheumatism (EULAR)/American College of Rheumatology (ACR) joint classification criteria for SLE in 2019. * no antibiotics have been taken in the past 2 weeks; Healthy control group: * Male or female patient volunteers aged 14-55 from the Health Examination Center of Nanfang Hospital, * Voluntary signing of informed consent; * No systemic disease; * According to the judgment of the researchers, healthy volunteers matching SLE group in age, gender and education level were selected as the control group; Exclusion Criteria: * Patients with other autoimmune diseases; * Brain imaging suggested central nervous system infection, space occupation and other manifestations. * Patients with malignant tumors and active tuberculosis; * Pregnancy, lactation or intended pregnancy, women of childbearing age do not use effective contraceptive measures (IUD, oral contraceptives and obstruction measures); * History of cerebrovascular disease not associated with SLE as determined by the investigator * The researcher judged that it is not suitable to participate in this researcher.