Previous studied have investigated the pathophysiological role and expression of Cathepsin K (Ctsk) , receptor activator of the NF-κB ligand (RANKL) and periostin in active periodontitis and peri-implantitis lesions. However, the potential influence of non-surgical periodontal therapy including scaling and root planning on the bone remodeling markers level over different trial times have not well determined. Thus, the current research is conducted to address this influence. Thus, the research question will be: In patients with periodontitis, does the level of bone remodeling markers altered after successful NSPT during different healing time periods?
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
25
subjects will be examined for clinical periodontal parameters, their saliva samples will be collected, and then receiving full scaling using ultrasonic device, and oral hygiene instructions and motivation. After one week, the same clinical parameters, saliva sampling will be taken, and received full root surface debridement (RSD) using curette hand instruments (Gracey, USA) (First visit). One month and three months after first visit, the same clinical measurements, saliva will characterize as second and third visits, respectively.
College of Dentistry, University of Baghdad
Baghdad, Iraq
Bone remodeling markers including salivary RANKL
To investigate the alterations in the level of salivary RANKL pg/ml following Non-surgical periodontal therapy in unstable periodontitis patients during different healing time periods.
Time frame: At a base line visit (Zero time visit), After one week (first visit), and One month and three months after first visit
Bone remodeling markers including salivary Cathepsin k
To investigate the alterations in the level of salivary Cathepsin k pg/ml following Non-surgical periodontal therapy in unstable periodontitis patients during different healing time periods.
Time frame: At a base line visit (Zero time visit), After one week (first visit), and One month and three months after first visit
Bone remodeling markers including salivary periostin
To investigate the alterations in the level of salivary periostin pg/ml following Non-surgical periodontal therapy in unstable periodontitis patients during different healing time periods.
Time frame: At a base line visit (Zero time visit), After one week (first visit), and One month and three months after first visit
Clinical periodontal parameters including Bleeding on probing
To measure Clinical periodontal parameters including Bleeding on probing following Non-surgical periodontal therapy in unstable periodontitis patients during different healing time periods.
Time frame: At a base line visit (Zero time visit), After one week (first visit), and One month and three months after first visit
Clinical periodontal parameters including probing pocket depth
To measure Clinical periodontal parameters including probing pocket depth following Non-surgical periodontal therapy in unstable periodontitis patients during different healing time periods.
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Time frame: At a base line visit (Zero time visit), After one week (first visit), and One month and three months after first visit
Clinical periodontal parameters including clinical attachment loss
To measure Clinical periodontal parameters including clinical attachment loss following Non-surgical periodontal therapy in unstable periodontitis patients during different healing time periods.
Time frame: At a base line visit (Zero time visit), After one week (first visit), and One month and three months after first visit