The aim of the study is to collect different parameters (clinical, biological and biometrological) of Atopic Dermatitis (AD) in order to identify which factors are modified during the flare-up phase.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
12
* Clinical evaluations * Non-invasive instrumental measurements * Subject's evaluations
Centre de Recherche sur la Peau
Toulouse, France
Assessment of clinical parameters in Atopic Dermatitis during and outside flares-up
* SCORAD (SCOring Atopic Dermatitis) and PO-SCORAD (Patient Oriented SCORing Atopic Dermatitis) are a scoring system based on the assessment of extent and intensity in a standardized manner * Target SCORAD is the sum of all SCORAD objective signs scores: erythema, oedema/papulation, oozing/crusts, excoriation, lichenification and dryness evaluated on a target area
Time frame: Change from baseline to 3 months
Colonization of microorganisms involved in Atopic Dermatitis flares-up from PCR analysis on a swab sample
Colonization of microorganisms will be expressed by percentage of each microorganism
Time frame: Change from baseline to 3 months
Assessment of lipids profiles in Atopic Dermatitis by mass spectroscopy from swab samples
Each characteristic peak corresponding to specific lipid will be quantified by its mass intensity
Time frame: Change from baseline to 3 months
Assessment of cutaneous hydratation in Atopic Dermatitis during and outside flares-up
Cutaneous hydration evaluated by humidity of the stratum corneum. The measurement is based on capacitance measurement of the stratum corneum.
Time frame: Change from baseline to 3 months
Assessment of skin barrier condition in Atopic Dermatitis during and outside flares-up
The measurement is based on Trans-Epidermal Water Loss measurement
Time frame: Change from baseline to 3 months
Assessment of pH in Atopic Dermatitis during and outside flares-up
pH evaluated by a pH-meters
Time frame: Change from baseline to 3 months
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Assessment of erythema in Atopic Dermatitis during and outside flares-up
Assessment the color of the surface of the skin
Time frame: Change from baseline to 3 months