The purpose of this study is to detect the efficacy of intranasal dexmedetomidine as a premedication to general anesthesia in pediatric patients with respiratory comorbidities undergoing adenotonsillectomy.
Respiratory comorbidities are associated with an increased incidence of peri-operative respiratory adverse effects (PRAE). Upper and lower respiratory infections, as well as asthma, are common in children who are scheduled for adenotonsillectomy. When compared to healthy children, children with respiratory ailments have a three-fold increase in PRAEs.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
70
That will receive intranasal dexmedetomidine (1.5mcg/kg)
That will receive the same volume of 2 ml of intranasal normal saline
Eman Ahmed Azzam
Tanta, El-Gharbia, Egypt
RECRUITINGThe incidence of peri-operative respiratory adverse effects (PRAE).
All PRAE and the time of occurrence (induction, maintenance or emergence) will be recorded.
Time frame: From induction to emergence from general anesthesia.
Sedating effects of this drug.
The sedating effects will be measure using Ramsay sedation scale from 1 to 6 as 1 meaning anxious and agitated, restless, or both. and 6 meaning Unresponsive.
Time frame: 15 and 30 min after sedation
Ease of parental separation.
Evaluated using a four-point scale. from 1 to 4 as 1 meaning excellent and 4 for poor
Time frame: 15 and 30 min after sedation
Face mask acceptance.
Evaluated using a four-point scale. from 1 to 4 as 1 meaning excellent and 4 for poor
Time frame: 15 and 30 min after sedation
Hemodynamic stability
hypertension, tachycardia, bradycardia
Time frame: 15 and 30 min after sedation
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