The aim of the study is to understand the structural and functional modifications of the host, the microorganisms, and their interactions (host/microorganism relationship) before and after the RV3278A - ET0943 product application
Study Type
OBSERVATIONAL
Enrollment
41
RV3278A - ET0943 study product is applied twice a day on the face during the whole study.
RV4632A - RY1845 study product must be applied only in case of sensation of skin discomfort
Centre de santé SABOURAUD C.E.P.C
Paris, France
Centre de Recherche sur la Peau
Toulouse, France
Effect of the RV3278A on acne severity
Global Evaluation Acne (GEA), on a 6-point scale 0: Clear. No lesions 1. Almost clear, Almost no lesions 2. Mild 3. Moderate 4. Severe 5. Very severe
Time frame: Change from baseline to 2 months
Effect of the RV3278A on inflammatory and retentionnal lesions
Quantification of inflammatory and retentionnal lesions from image analysis
Time frame: Change from baseline to 2 months
Effect of the RV3278A on microorganisms
Quantitative analysis by ddPCR (droplet digital Polymerase Chain Reaction) from comedones samples
Time frame: Change from baseline to 2 months, for each group
Effect of the RV3278A on microorganisms
Qualitative analysis by 2 and 3-dimensional electron microscopy from comedones samples
Time frame: Change from baseline to 2 months
Effect of the RV3278A on metabolites
Metagenomic analysis on comedones samples
Time frame: Change from baseline to 1 month
Effect of the RV3278A on lipids
Lipids PCR (Polymerase Chain Reaction) analysis done by SpiderMass tool from cigarette paper and comedones samples
Time frame: Change from baseline to 2 months
Effect of the RV3278A on lipids
Qualitative analysis by 2 and 3-dimensional electron microscopy from comedones samples
Time frame: Change from baseline to 2 months
Effect of the RV3278A on hyperkeratosis
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Qualitative analysis by 2 and 3-dimensional electron microscopy from comedones samples
Time frame: Change from baseline to 2 months
RV3278A product tolerance
Adverse events occurrence will be determined by the subject's / parent(s) or guardian(s) spontaneous reporting, the investigator's non-leading questioning, and his/her clinical evaluation
Time frame: From Day 1 to 2 months