Antenatal Corticosteroid Therapy: Which Impact on Birth Parameters?

Central Hospital, Nancy, France363 enrolled

Overview

Use of antenatal corticosteroids therapy has increased since the 2000s. The benefits of such a therapy on premature newborns are scientifically and internationally recognized. Nevertheless, few studies have been conducted to investigate the impact of this antenatal corticosteroid therapy on full-term newborns (\> 36 weeks' gestation). The aim of this study is to compare the birth parameters of full-term newborns exposed or not to antenatal corticosteroid therapy.

All children included in the study were born at the Regional Maternity Hospital of Nancy between January 1, 2014 and December 31, 2020. One hundred and twenty-one of them were exposed during pregnancy to antenatal corticosteroids therapy and constitute the exposed arm, whereas 242 were not and constitute the non-exposed arm. Data were collected retrospectively regarding history of pregnancy, birth parameters and neonatal adaptation.

Study Type

OBSERVATIONAL

Enrollment

363

Conditions

Growth Retardation

Interventions

BetamethasoneDRUG

Eligibility

Sex: ALLMax age: 12 Months

Medical Language ↔ Plain English

Inclusion Criteria: * all children exposed to an antenatal corticosteroid therapy before 34 weeks of amenorrhea because of a threat of premature delivery * only full-term newborns Exclusion Criteria: * all children exposed to an antenatal corticosteroid therapy before 34 weeks of amenorrhea for other reasons

Outcomes

Primary Outcomes

Evaluate the impact of an antenatal corticosteroid therapy on head growth.

head circumference

Time frame: Birth

Secondary Outcomes

Evaluate the impact of an antenatal corticosteroid therapy on fetal weight

birth weight

Time frame: Birth

Evaluate the impact of an antenatal corticosteroid therapy on fetal growth

birth lenght

Time frame: birth

Evaluate the impact of an antenatal corticosteroid therapy on neonatal adaptation : APGAR score for each patient

APGAR score

Time frame: birth

Evaluate the impact of an antenatal corticosteroid therapy on risk of hypoglycemia : number of patients with neonatal hypoglycémia

hypoglycemia

Time frame: first 5 days

Evaluate the impact of an antenatal corticosteroid therapy on risk of hypocalcemia : number of patients with hypoglycemia

hypocalcemia

Time frame: first 5 days

Evaluate the impact of an antenatal corticosteroid therapy on neonatal outcome : number of days of hospitalisation after birth

day of hospitalisations after birth

Time frame: first 5 days

Evaluate the impact of an antenatal corticosteroid therapy on eating disorders (number of patients with difficulty to drink)

eating disorders

Data from ClinicalTrials.gov

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