Safety and Effectiveness of BioTraceIO 360 for Planning, Monitoring and Assessment of Liver Tissue Ablation Procedures (PANORAMA2)

Inclusion Criteria: * Scheduled and indicated for standard-of-care liver tumor ablation for either hepatocellular carcinoma (HCC) or metastatic liver tumor(s) microwave (MW) energy. * Patient must have at least one prior CT or CECT scan (up to 6 months before enrollment). * Tumor must be visualized on at least one diagnostic imaging modality (MRI or contrast-enhanced CT). * Single tumor, or multiple tumors only if the distance between the ablated tumor and all other tumors allows for distinct separation between the necrotic zones. * Distance between the tumor and the edge of any previous necrotic zones allows for distinct separation between the necrotic zones. * At least 21 years of age. * Able and willing to give informed consent. Additional inclusion criteria for subgroup: \- Single ablation, using a single ablation needle, per tumor. Exclusion Criteria: * Planned ablation includes adjunctive means other than MW energy (e.g., ethanol, hepatic artery embolization, etc.). * Planned ablation includes the use of more than two ablation needles, per tumor * Ablation area cannot be visualized and monitored continuously using ultrasound throughout the entire ablation procedure. * Pregnant or breastfeeding. * Patient judged unsuitable for study participation by the physician for any other reason. * Currently participating in another clinical trial of an unapproved investigational device or drug that has not concluded the follow-up period. * Unable or unwilling to give informed consent. Additional exclusion criteria for subgroup: * Liver tumor that cannot be ablated with a single ablation needle, according to the investigator's clinical opinion. * Planned ablation includes repositioning and/or overlapping ablations using a single ablation needle.