To explore the PK/PD of deoxycholic amphotericin B in invasive fungal infection patients with sepsis/septic shock;To compare the PK/PD of deoxycholic amphotericin B in invasive fungal infection patients with sepsis and septic shock.
This was a single-center study.Patients who were diagnosed with in invasive fungal infection receieved deoxycholic acid amphotericin B during the study period.The information was recored including the general condition, infection index, PK/PD index and drug-related side effects.
Study Type
OBSERVATIONAL
Enrollment
20
Starting with 1mg and increasing by 5-25mg daily until the maintenance dose is 50mg/d.
Zhongda Hospital, Southeast University
Nanjing, Jiangsu, China
Zhongda Hospital
Nanjing, Jiangsu, China
Cmax/MIC
PK/PD of Deoxycholic Acid Amphotericin B
Time frame: 14 days
AUC24h/MIC
Concentration of Deoxycholic Acid Amphotericin B
Time frame: 14 days
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.