Current clinical cameras do not allow clinicians to see the cells of the retina. This study will evaluate a new electronic camera's ability to observe the human retina in finer detail.
This research study will (1) test the ability of a new electronic camera developed in Dr. Miller's laboratory to observe retina in human subjects, and (2) use the camera for observing disease in the eye. This new camera integrates cutting-edge technologies in adaptive optics (AO) and optical coherence tomography (OCT) that enable the camera to capture sharp images. The objective of our study is to find out (1) whether the AO-OCT camera will allow researchers to observe the retina with finer resolution than current clinical cameras, and (2) whether this finer detail is useful for observing the progression of disease in the eye. To address the second objective, the study will subjects with various disease severity of drusen associated geographic atrophy.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DEVICE_FEASIBILITY
Masking
NONE
Enrollment
5
AO-OCT used in this study is an investigational OCT imaging system. In this instrument, ocular aberration sensing and correction is achieved with a Shack-Hartmann wavefront sensor (SHWS) and deformable mirror, respectively. A pupil camera and fixation target are used to position the participant's head and eye for scanning a particular retinal region within 15 degrees of the fovea. Data collected generally includes AO-OCT volume videos and SHWS measurements of ocular aberrations.
Indiana University School of Optometry
Bloomington, Indiana, United States
Quality of photoreceptor and retinal pigment epithelium (RPE) cell layers
Images of the photoreceptor and RPE cell layers taken with clinical instruments and the AO-OCT will be compared.
Time frame: 2 years
RPE cell morphology changes
Images will be used to determine the changes in RPE cell morphology in regions of healthy and diseased retina (in subjects with retinal disease).
Time frame: 2 years
Cone Photoreceptor Dysfunction
Images will be used to determine changes in cone photoreceptor dysfunction and death
Time frame: 2 years
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