The purpose of this retrospective study was to clarify the possible risk factors of early hypothyroidism after RAI therapy in Graves' disease.
Hyperthyroidism is a clinical syndrome caused by increased thyroid hormone in the blood, it can lead to multiple complications, including cardiac, hepatic, and hematologic system complications. More than 80% of hyperthyroidism are caused by Graves' disease (GD). 3% of women and 0.5% of men may suffer GD in their lifetime \[1\]. Radioactive iodine (RAI) therapy is an important treatment option for Graves' disease (GD), the main side effect of RAI treatment is hypothyroidism, and the factors resulting in hypothyroidism are still controversial \[2\]. Male gender, smaller thyroid weight, higher thyroid-stimulating hormone, and smaller thyroid volume are Suggested to be the main risk factors for early hypothyroidism \[2\]-\[3\].
Study Type
OBSERVATIONAL
Enrollment
300
All the patient need to stop ATD and iodine-containing drugs for 5 days prior to RAI treatment, and followed a low-iodine diet for 2 weeks. After fasting and water deprivation for 8 h, all the patients took RAI orally in the morning. After taking RAI, the patients need to continue fasting and water deprivation for extra 2 h to avoid the effects of food on iodine absorption.
Nuclear medicine unit, department of clinical oncology and nuclear medicine, Assiut university hospital
Asyut, Egypt
RECRUITINGpredictive factors of early hypothyroidism after RAI therapy
Retrospective study from 2013 to 2022 to analyze the correlation between clinical, demographic\& and laboratory data and incidence of hypothyroidism by measuring thyroid function tests
Time frame: 1 year
the incidence of hypothyroidism within 1 year
To detect the frequency of hypothyroidism after RAI and when it is most likely occur after 6 months or one year
Time frame: 10 years
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