The goal of this interventional study is to test the influence of food intake with characteristics of the urinary bladder. The main questions it aims to answer are: * How does food intake modify the characteristics of urothelial cells? * Does change of specific diet regimes influence biomarker characteristics in urine? Participants will follow specific diet regime for a given time period. After completion of this period biomarker assessment is performed. Thereafter the participants follow an opposite diet regime for the same time period with identical biomarker assessment at the end. Biomarkers within the participants and between the diet regimes will be compared to investigate the influence of food intake on the urinary bladder.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
13
Food intake will follow a recommendation according to a specific list. Protective and non-protective food intake will be performed for specific time periods with biomarker assessment after each period.
Department of Urology, Spitalzentrum Biel
Biel/Bienne, Canton of Bern, Switzerland
Roland Seiler
Biel, Switzerland
Change in molecular profile of urothelial cells
After the 12 week diet period (protective and non-protective), cells voided in urine will be sampled and examined.
Time frame: 12 weeks
Change in multiplex cytokine levels in voided urine
After the 12 week diet period (protective and non-protective), supernatant in voided urine will be used for further examination
Time frame: 12 weeks
DNA sequences in urinary microbiome
After the 12 week diet period (protective and non-protective), DNA sequencing on urinary microbiome in voided urine will be performed and compared between the different dietary regimens.
Time frame: 12 weeks
Change of BMI
After the 12 week diet period (protective and non-protective) BMI will be assessed.
Time frame: 12 weeks
Change of heart rate
After the 12 week diet period (protective and non-protective), heart rate will be assessed.
Time frame: 12 weeks
Change of blood pressure
After the 12 week diet period (protective and non-protective), systolic and diastolic blood pressure will be assessed.
Time frame: 12 weeks
Change of health status
After the 12 week diet period (protective and non-protective), health status will be assessed using the Short Form 36 (SF-36) questionaire. The possible score ranges from 0 to 100 points, with 0 points representing the greatest possible health limitation, and 100 points representing no health limitation.
Time frame: 12 weeks
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