This trial is a prospective, monocentric, non-therapeutic, interventional cohort study aiming to decipher the immune TME through standard neoadjuvant CT in resectable G/GEJ adenocarcinomas. This study will also longitudinally monitor MRD during neoadjuvant and adjuvant therapy.
Study Type
OBSERVATIONAL
Enrollment
50
Centre Léon Bérard
Lyon, France
RECRUITINGDescribe Gastric and Gastroesophageal immunological tumor microenvironment
Spatial, spectral cytometry, and transcriptomic analyses
Time frame: At least 36 months following inclusion
Understand the evolution of the immune tumor microenvironment and its spatial structuration through standard neoadjuvant chemotherapy.
Time frame: At least 36 months following inclusion
Characterize the evolution of the immune tumor environment profiles and organization between responder and non-responder patients under standard neoadjuvant treatment.
Time frame: At least 36 months following inclusion
Characterize the immune profile in lymph nodes after surgery (lymphadenectomy) between responder and non-responder patients to neoadjuvant under standard neoadjuvant treatment.
Time frame: At least 36 months following inclusion
Assess the phenotype and functions of circulating immunes cells
Time frame: At least 36 months following inclusion
Perform integrative analysis combining spatial, molecular, single cell RNAseq, and spectral flow cytometry analysis on the immunological tumor environment in matched tumor tissues longitudinally
Time frame: At least 36 months following inclusion
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.