Recent researches have reported that biologics might be also effective for stricturing CD. However, the data were largely retrospective. Prospective studied are needed for evaluate the efficacy of biologics for stricturing Crohn's diseases.
Study Type
OBSERVATIONAL
Enrollment
200
treat these patients with biologics
Department of General Surgery, Jinling hosptal,Medical School of Nanjing University
Nanjing, Jiangsu, China
RECRUITINGclinical remission rate at 1 year
clinical remission rate at 1 year (CDAI less than 150)
Time frame: clinical remission rate at 1 year
clinical remission rate at 5 year
clinical remission rate at 5 year (CDAI less than 150)
Time frame: clinical remission rate at 5 year
surgical recurrence rate at 1 and 5 year
surgical recurrence : needing surgery for CD recurrence
Time frame: at 1 and 5 year
endoscopic recurrence rate at 1 and 5 year
endoscopic recurrence: rutgeerts over i2b
Time frame: at 1 and 5 year
quality of life of patients assessed by IBDQ
IBDQ
Time frame: at 2, 4, 6 , 8 months and at 1, 2, 3, 4 and 5 year
quality of life of patients assessed by Short form 12
Short form 12
Time frame: at 2, 4, 6 , 8 months and at 1, 2, 3, 4 and 5 year
score of obstructive
range 0-6, higher means severe
Time frame: at 2, 4, 6 , 8 months and at 1, 2, 3, 4 and 5 year
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