Soluble VE-cadherin in Prediction and Diagnosis of Early Postoperative Hypoxemia After Cardiopulmonary Bypass

Zhuan Zhang100 enrolled

Overview

More than 2 million patients worldwide receive heart surgery every year, majority of these surgical patients will undergo cardiopulmonary bypass. However, the incidence of postoperative acute lung injury due to cardiopulmonary bypass is still as high as 20% to 35%. According to clinical experience, the earlier lung damage is detected, the more successful the treatment will be. On the basis of traditional detection, the investigators found a new indicator, serum soluble vascular endothelial-cadherin, which are easy to obtain and have certain specificity. Importantly, they can predict postoperative acute lung injury within 1 hour after cardiac surgery. It is meaningful that this indicator can provide clinicians with early decision-making advice and immediate treatment for patients who may be at risk.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

TRIPLE

Enrollment

100

Conditions

Hypoxemia ARDS Lung Injury, Acute Cardiopulmonary Bypass

Interventions

blood cell analysis, blood gas surveillance, chest radiograph and echocardiographyDIAGNOSTIC_TEST

Laboratory parameters of all postoperative patients including blood cell analysis, blood gas surveillance, liver, and kidney function alone with chest radiograph and echocardiography were dynamically monitored.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 18 years; * Underwent cardiac surgery using CPB technology. Exclusion Criteria: * Patient's lack of consent to participate; * Presence of abnormal liver, kidney or other organ function; * Pulmonary inflammation, chronic obstructive pulmonary disease or tumors; * Underwent cardiac surgery without CPB technology; * Postoperative need for extracorporeal membrane oxygenation support.

Outcomes

Primary Outcomes

PaO2/FiO2 ratio

The ratio of inspiratory oxygen fraction to oxygen pressure (PaO2/FiO2) was calculated

Time frame: Day 1 after CPB, Day 2 after CPB

lung-injury scores

A structured tutorial was used to establish consensus in the interpretation of radiographs for radiographic lung-injury scores, range from 0 to 4. 0: No alveolar consolidation; 1: Alveolar consolidation confined to 1 quadrant; 2: Alveolar consolidation confined to 2 quadrants 3: Alveolar consolidation confined to 3 quadrants; 4: Alveolar consolidation in all 4 quadrants. The higher scores mean a worse outcome.