Features of Regional Perfusion of Lung Consolidation

Peking Union Medical College Hospital200 enrolled

Overview

The aim of this study is to evaluate the potential usefulness of lung ultrasound to assess the size and perfusion of consolidation and explore their relationships with clinical outcome.

Lung consolidation is one of the most causes of hypoxia in intensive care unit(ICU) settings. A quantitative measurement of consolidation would be extremely benefit for the clinical management in hypoxemia, both as an index of severity and to predict outcomes.In order to quantify the lung consolidation and its effect on clinical outcomes, a simple and quantitative scoring system of the size and perfusion of lung consolidation was proposed by lung ultrasound. Subjects with respiratory failure and lung consolidation proved by chest imaging underwent lung ultrasound examination. The size of consolidation and the richness of blood flow was computed upon lung ultrasound. The sensitivity, specificity and accuracy of the scoring system were calculated and compared to evaluate the diagnostic efficacy.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Lung Injury, Acute Ultrasound Therapy; Complications

Interventions

UltrasoundDIAGNOSTIC_TEST

Each patient underwent ultrasound after admission of ICU.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion criteria: 1. Admission to ICU( 18yr\<age\<90yr); 2. Patients presented with acute respiratory failure; 3. Pulmonary consolidation by chest imaging (lung ultrasound, X ray or CT scan). Exclusion criteria: 1. Hemodynamic instability (i.e., severe hypotension with systolic arterial pressure\<60mmHg despite fluid expansion and vasoactive support; systolic arterial pressure\>180mmHg; uncontrolled cardiac arrhythmias); 2. Severe thoracic trauma; 3. Coronavirus disease 2019; 4. Pulmonary artery hypertension and pregnancy.

Locations (1)

Peking union medical college hospital

Beijing, Beijing Municipality, China

RECRUITING

Outcomes

Primary Outcomes

consolidation area index

The volume of consolidation was measured by consolidation area index (CAI) which is calculated from two-dimensional measures, namely the product of the core distance (from the bottom to the top of the screen) and the longitudinal distance (from the left to the right of the screen).

Time frame: through study completion, an average of 2 year

blood flow score

A semi-quantified scoring system based on the richness of flow signals was established. It identifies four progressive steps of blood signals, each corresponding to a score: no pulsatile blood flow-score 0; sparse dot-like blood flow-score 1; pronounced curvilinear vascularity-score 2; tree-like vascularity-score 3.

Time frame: through study completion, an average of 2 year

Central Contacts

Na Wang, MD

CONTACT

17810258960 wangna_pumch2017@163.com

Huaiwu He, MD

CONTACT

010-69152300 timuhhw@126.com

Data from ClinicalTrials.gov

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