Immune Profile Analysis and Biomarker Identification in Women With Repeated Implantation Failure or Unexplained Recurrent Spontaneous Miscarriage

Inclusion Criteria: * For patients : * Women aged 18 to 39 years * women with a history of RIF or unexplained RM * women with a negative diagnostic work-up (including pelvic ultrasound and hysteroscopy, parental karyotype, thyroid function test, and anti-thyroid and anti-phospholipid antibodies) * women with a basal FSH level \<10IU/l and AMH level \>1.5ng/ml * women with a regular menstrual cycle of 30+/-5 days * women receiving a new cycle of in vitro fertilization (IVF) +/- intracytoplasmic sperm injection (ICSI) for patients in the RIF group or a first cycle of IVF +/-ICSI for patients in the RM group * women received written and oral information and signed an informed consent For control groups: * Controls recruited in the Obstetrics and Gynecology Department with at least one live birth after a spontaneous pregnancy (with a time to conception of less than 12 months for each pregnancy) Voluntary oocyte donors recruited within the CECOS de Picardie (having presented at least one live birth with a delay necessary to conceive of less than 12 months) * Controls recruited in the Reproductive Medicine and Biology Department having presented at least one live birth (spontaneous with a delay to conceive of less than 12 months for each pregnancy or after one or two MPA procedures) and benefiting from an IVF+/-ICSI procedure for secondary infertility * Controls recruited in the department of Medicine and Reproductive Biology with a normal infertility assessment and benefiting from an IVF procedure with ICSI on male indication. Exclusion Criteria: * Ongoing pelvic and/or systemic infection * Chronic infectious endometritis * Active neoplasia * Autoimmune and autoinflammatory disease * Celiac disease * Thrombophilia (including positive anti-phospholipid antibodies) * Endocrine pathology (including dysthyroidism and diabetes) * Endometriosis * Polycystic ovary syndrome and ovulatory disorders * Premature ovarian failure * IVF by oocyte donation * Tubal obstructions or lesions, uterine and cervical anomalies * Partners with extreme oligoastheno-spermia and/or sperm DNA fragmentation \>30 * Sperm donations * Patients unable to give informed consent