The study authors hypothesize that in patients with intestinal polyps, tumor cells could disseminate and circulating factors could be secreted by the polyp. These two parameters could become biomarkers to refine the follow-up of patients and to establish targeted therapeutic strategies.
Study Type
OBSERVATIONAL
Enrollment
120
Venous blood samples taken at the moment of colonoscopy to test for biomarkers
CHU de Nîmes
Nîmes, France
Dissemination of circulating tumor cells in blood samples from patients with intestinal polyps compared to patients without polyps
Number of disseminated circulating tumor cells found on the ANGLE Parsortix™ system
Time frame: Day 0
Concentration of Macrophage Colony Stimulating Factor (M-CSF) in the blood samples between groups
ng/mL, measured by Enzyme-Linked ImmunoSorbent Assay
Time frame: Day 0
Concentration of Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) in the blood samples between groups.
ng/mL, measured by Enzyme-Linked ImmunoSorbent Assay
Time frame: Day 0
Concentration of Chemokine ligand 2 (CCL-2) in the blood samples between groups.
ng/mL, measured by Enzyme-Linked ImmunoSorbent Assay
Time frame: Day 0
Concentration of keratinocyte-derived cytokine (CXCL-1) in the blood samples between groups
ng/mL, measured by Enzyme-Linked ImmunoSorbent Assay
Time frame: Day 0
Concentration of Tissue Inhibitor of Metalloproteinase 1 (TIMP-1) in the blood samples between groups
ng/mL, measured by Enzyme-Linked ImmunoSorbent Assay
Time frame: Day 0
Concentration of Stromal cell-Derived Factor 1 (SDF-1) in the blood samples between groups
ng/mL, measured by Enzyme-Linked ImmunoSorbent Assay
Time frame: Day 0
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Anti-aggregant therapy according to presence of circulating tumor cells, cytokine presence and presence of polyp
Yes/no
Time frame: Day 0
Anti-coagulant therapy according to presence of circulating tumor cells, cytokine presence and presence of polyp
Yes/no
Time frame: Day 0
Known intestinal pathology according to presence of circulating tumor cells, cytokine presence and presence of polyp
Yes/no
Time frame: Day 0
Reason for screening colonoscopy according to presence of circulating tumor cells, cytokine presence and presence of polyp
Fecal immunochemical test positive / Personal history of colonic adenoma / Family history of colonic adenoma / Personal history of colorectal cancer / Family history of colorectal cancer / Rectal symptoms
Time frame: Day 0
Screening colonoscopy operator (inter-operator tumor detection rate) according to presence of circulating tumor cells, cytokine presence and presence of polyp
Time frame: Day 0
Quality of the preparation according to presence of circulating tumor cells, cytokine presence and presence of polyp
Boston classification: ranked from 0 to 3 for each colonic segment explored
Time frame: Day 0
Caecal intubation rate according to presence of circulating tumor cells, cytokine presence and presence of polyp
classed as complete colonoscopy after visualization of the caecal floor
Time frame: Day 0
Per-surgical complications according to presence of circulating tumor cells, cytokine presence and presence of polyp
Post-polypectomy bleeding / Perforation / Incomplete colonoscopy / No complications
Time frame: Day 0
Total number of colonic adenomas visualized according to presence of circulating tumor cells, cytokine presence and presence of polyp
Number
Time frame: Day 0
Total number of histologically validated resected colonic adenomas according to presence of circulating tumor cells, cytokine presence and presence of polyp
Number
Time frame: Day 0
Size of resected adenomas according to presence of circulating tumor cells, cytokine presence and presence of polyp
\< 5mm / 5 - 10mm / \> 10mm
Time frame: Day 0
Location of resected adenomas according to presence of circulating tumor cells, cytokine presence and presence of polyp
Rectum / Sigmoid / Left Colon / Transverse Colon / Right Colon / Caecum
Time frame: Day 0
Morphology of resected adenomas according to presence of circulating tumor cells, cytokine presence and presence of polyp
Paris classification: 0-Is / 0-Ip / 0-IIa / 0-IIb / 0-IIc / 0-III
Time frame: Day 0
Method of resected adenomas according to presence of circulating tumor cells, cytokine presence and presence of polyp
Biopsy forceps / Cold loop / Diathermic loop / Mucosectomy / Unresected (Suspected Cancer, Unresectable in ambulatory)
Time frame: Day 0
Recovery of the adenoma after resection according to presence of circulating tumor cells, cytokine presence and presence of polyp
Yes/no
Time frame: Day 0
Histology of resected adenomas according to presence of circulating tumor cells, cytokine presence and presence of polyp
Vienna classification: Nonspecific (Food Residue, Normal Mucosa or Colonic Fold) / Adenoma in Low Grade Dysplasia / Adenoma in High Grade Dysplasia / Cancer - Transformed Adenoma / Scalloped Adenoma / Hyperplastic Polyp.
Time frame: Day 0
Location of resected adenomas according to presence of circulating tumor cells, cytokine presence and membrane marker expression
Rectum / Sigmoid / Left Colon / Transverse Colon / Right Colon / Caecum
Time frame: Day 0