Effects of Intrathecal Local Anesthetics on Left Ventricular Global Longitudinal Strain

Milton S. Hershey Medical Center10 enrolled

Overview

The objective of this study is to assess the effects of intrathecal local anesthetics on left ventricular global longitudinal strain (LVGLS) using transthoracic echocardiography (TTE).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Left Ventricular Dysfunction Spinal Anesthetics Causing Adverse Effects in Therapeutic Use Global Cardiac Wall Motion Dysfunction

Interventions

Intrathecal local anesthesiaDRUG

Administration of local anesthetic into intrathecal space to achieve surgical anesthesia

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients undergoing elective knee and hip replacements under spinal anesthesia Exclusion Criteria: * Patients who do not wish to consent * Patients with contraindications to TTE * Patients with reduced left ventricular systolic function as defined by LV ejection fraction \< 50% on pre-operative echocardiography * Patients with body mass index greater than 40 * Non-English-speaking subjects * Cognitively impaired adults

Locations (1)

Milton S. Hershey Medical Center

Hershey, Pennsylvania, United States

Outcomes

Primary Outcomes

Left Ventricular Global Longitudinal Strain

Time frame: 5 minutes

Secondary Outcomes

Left Ventricular Ejection Fraction

Time frame: 5 minutes

Data from ClinicalTrials.gov

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