A Study of B1962, a PD-L1/VEGF Bispecific Antibody Fusion Protein, for Advanced Solid Tumors

Inclusion Criteria: 1. written and signed informed consent. 2. Age ≥ 18 years and ≤ 75 years at the time of signing the informed consent form. 3. Patients with histologically or cytologically confirmed advanced malignant solid tumors who have failed or failed to respond to standard therapy, or who are intolerant of standard therapy, or who have no standard effective treatment regimen, or who have refused standard therapy (posterior and endline). 4. willing and able to comply with all study procedures. 5. Eastern Cooperative Oncology Group (ECOG) Performance Score of 0 or 1. 6. Life expectancy ≥ 3 months. 7. Subjects must have at least one measurable lesion according to RECIST Version 1.1 8. Adequate organ and bone marrow function 9. Females of childbearing potential and non-sterilized males who are sexually active must use an effective method of contraception from screening until 120 days after final dose of investigational product or women of non child bearing potential. Exclusion Criteria: 1. Patients receiving immune checkpoint inhibitors (ICIs) or VEGF/VEGFR inhibitors within 28 days prior to the first dose of the study drug. 2. Known allergy or reaction to any component of the B1962 formulation or history of severe hypersensitivity reactions to other large protein agents/mAbs or BsAbs. 3. Female patients who are pregnant or breastfeeding. 4. Subjects has received major surgical procedure within 4 weeks prior to the first dose of B1962, or is scheduled to receive major surgical procedure during the current study period 5. Unresolved toxicities from prior anticancer therapy, defined as having not resolved to NCI CTCAE v5.0 Grade 0 or 1 (except for alopecia). 6. Patients with untreated or clinically symptomatic brain metastases, spinal cord compression, cancerous meningitis, or other evidence that the patient's brain or spinal cord metastases have not been controlled (except in cases where the patient has been treated and has stable symptoms, imaging shows stability for at least 4 weeks prior to the first dose, and there is no evidence of brain edema and no need for glucocorticoid therapies) 7. Patients with clinically symptomatic or recurrent pleural effusions, pericardial effusions or ascites requiring repeated drainage 8. Imaging at the screening period showed that the tumor was wrapped around important blood vessels or had significant necrosis or cavitiation, and the investigators judged that entering the study would cause bleeding risk 9. Known history of HIV infection or acquired immunodeficiency syndrome-related disease 10. Patients with hepatitis B or C infection; or known active syphilis infection. 11. Uncontrolled infections requiring systemic therapy within 4 weeks prior to the first dose of study drug. 12. Subjects with clinically significant cardiovascular disease; uncontrolled hypertension (SBP ≥ 140 mmHg or DBP ≥ 90 mmHg) or poor compliance with antihypertensive therapy; major vascular disease. 13. History of Coagulation disorders, bleeding disorders, or other conditions judged by the investigator to be a risk of bleeding within 6 months prior to the first dose. 14. pulmonary hemorrhage/hemoptysis ≥ grade 2 (according to NCI-CTCAE v5.0) within 1 month prior to first drug administration 15. biopsy or other minor surgery, excluding placement of vascular access devices, within 7 days prior to the first dose of B1962 16. History of arterial or venous thrombosis, or stroke or transient ischemic attack within 6 months prior to the first dose of B1962 17. Current unstable dose of anticoagulant or thrombolytic medication within 14 days of the first dose of B1962. Note: prophylactic use of low molecular heparin is acceptable. 18. Aspirin (\> 325 mg/day) or NSAIDs treatment within 14 days of first dose of B1962 19. Uncontrolled diabetes mellitus (HbA1c \>8%) on standard therapy 20. Active or prior documented idiopathic pulmonary fibrosis or idiopathicpneumonia; current acute lung disease, interstitial lung disease or pneumonia (except localized interstitial pneumonia due to radiotherapy induction), pulmonary fibrosis, etc.; severe respiratory distress, pulmonary insufficiency or continuous oxygenation 21. Active or prior documented of autoimmune disease requiring systemic therapy within 2 years prior to screening. Note: Enrollment is permitted in the following conditions: hypothyroidism that can be controlled by hormone replacement therapy alone, skin conditions that do not require systemic therapy (e.g. vitiligo, psoriasis), and controlled celiac disease. 22. Subjects with a condition requiring systemic treatment with either corticosteroid (\> 10 mg daily ) or other immunosuppressive medications within 14 days of first study drug administration (topical or physiological hormones dose is acceptable) 23. Receipt of any systemic anticancer therapy within 4 weeks or 5 half-lives (whichever is longer) prior to first dose, small molecule tyrosine kinase-targeted agents therapy or immunomodulatory therapy within 2 weeks prior to first dose; or herbal or proprietary Chinese medicines with antitumor indications within 1 week prior to the first dose. 24. For hepatocellular carcinoma: receipt of local area treatment of the liver within 4 weeks prior to the first dose of B1962 25. History of organ or hematopoietic stem cell transplantation requiring immunosuppressive medications 26. History of other neoplasms within 5 years prior to screening, except basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or cervical cancer in situ that has undergone successful radical surgery 27. Received attenuated vaccination within 4 weeks prior to screening or planning to receive attenuated vaccination during the study period 28. Patients who have participated in a clinical study and received study drug within 4 weeks or 5 half-lives (whichever is longer) prior to the first dose 29. History of alcohol or drug abuse within 12 months prior to the first dose. 30. Known history of psychiatric disorder that may affect trial compliance 31. Other serious systemic disease, abnormal laboratory tests, or other reasons deemed inappropriate for subjects by the investigator