Changes in Tactile Perception in People With Segmental Exclusion Syndrome

Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est34 enrolled

Overview

Segmental exclusion syndrome is characterised by the non-use or under-use of a limb segment, most oftenly reported in the distal part, following an injury, without affecting the central nervous system. This syndrome has an important negative impact on the daily life of affected subjects; however, it remains poorly studied, particularly in terms of pathophysiology, and its management is still not specific. Currently, the main pathophysiological hypothesis is an alteration of the afferences related to a dysfunction of the sensorimotor loop. An hypothesis is that this dysfunction could concern the level of tactile perception and that the damage to the distal light touch receptors could play a role in the pathophysiology. The protocol is based on the performance of tests that explore different aspects of light touch: passive, active, dynamic and static sensitivity.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Upper Limb Exclusion Syndrom

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * No history of upper limb involvement * Confirmed diagnosis of segmental exclusion \> 3 months after injury (2 items assigned to 400 points) * Able to understand simple orders Exclusion Criteria: * Central neurological involvement after the initial or pre-existing injury * Truncal nerve damage * Presence of psychiatric pathology * Communication and/or comprehension disorders * Presence of other pathology that may lead to sensory disorders (complicated diabetes, ductal syndrome, ...)

Locations (1)

Outcomes

Primary Outcomes

Difference in passive sensitivity discrimination orientation threshold between each hand in static condition.

Difference in thresholds of sensitive discrimination between the two hands in the Grating Orientation Task (mm)

Time frame: once during the one-day evaluation session

Difference in passive sensitivity discrimination threshold between each hand in static condition.

Difference in thresholds of sensitive discrimination between the two hands in the Static Two Points discrimination test (mm)

Time frame: once during the one-day evaluation session

Difference in passive sensitivity discrimination of pressure threshold between each hand in static condition.

Difference in thresholds of sensitive discrimination between the two hands in the monofilament test (Newton)

Time frame: once during the one-day evaluation session

Difference in passive sensitivity discrimination threshold between each hand in dynamic condition.

Difference in thresholds of sensitive discrimination between the two hands in Moving Two-Points Discrimination Test (mm)

Time frame: once during the one-day evaluation session

Secondary Outcomes

Difference in active sensitivity discrimination threshold between each hand in dynamic condition.

Percentage of correct answers to the bar test in both groups.

Time frame: During the evaluation session