Impact of Prophylactic Antibiotics on Bloodstream Infections After Liberation From Extracorporeal Membrane Oxygenation

Universität des Saarlandes42 enrolled

Overview

The goal of this prospective interventional study is to evaluate the impact of antibiotic prophylaxis on bloodstream infections after liberation of extracorporeal membrane oxygenation therapy. The main questions aims to answer are: • does application of vancomycine prior to ECMO liberation have an impact of bloodstream infections? Participants will get 1 dose of vancomycine I.V. (15-20 mg per kgKG) prior to liberation of ECMO. Researchers will compare this interventional group to a group without antibiotic prophylaxis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Catheter-Related Infections

Interventions

Vancomycine

Application of 15-20 mg per kgKG Vancomycine I.V. prior to ECMO liberation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adult patients older than 18 years * ECMO-Therapy Exclusion Criteria: * patients younger than 18 years * fever \>38,5°C * pregnancy * antibiotic treatment with Vancomycine, Linezolid, Daptomycin or Tygacil on the day of liberation * prior adverse events after application of Vancomycine

Locations (1)

University Hospital of Saarland

Homburg, Saarland, Germany

Outcomes

Primary Outcomes

Growth of pathogens in blood culture

Detection of pathogens / blood stream infection

Time frame: taken 72 hours after liberation of extracorporeal membrane oxygenation therapy

Growth of pathogens in blood culture

Detection of pathogens / blood stream infection

Time frame: taken directly before removal of extracorporeal membrane oxygenation therapy

Secondary Outcomes

Growth of pathogens on cannula tip

Detection of growth of pathogens on cannulas

Time frame: on the day of liberation, cannula tip will be send to institute of microbiology directly after liberation from ECMO

laboratory parameters

leukocytes, procalcitonin, C-reactive protein

Time frame: 6.00 am on the day of liberation of extracorporeal membrane oxygenation therapy

laboratory parameters

leukocytes, procalcitonin, C-reactive protein

Time frame: 24 hours after liberation of extracorporeal membrane oxygenation therapy

laboratory parameters

leukocytes, procalcitonin, C-reactive protein

Time frame: 48 hours after liberation of extracorporeal membrane oxygenation therapy

laboratory parameters

leukocytes, procalcitonin, C-reactive protein

Time frame: 72 hours after liberation of extracorporeal membrane oxygenation therapy

Central Contacts

Carsten Zeiner, MD

CONTACT

+49684116 carsten.zeiner@uks.eu

Philipp M Lepper, MD

CONTACT

+49684116 philipp.lepper@uks.eu

Data from ClinicalTrials.gov

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