Acute Oral Ketones or Carbohydrate Supplement Modify Heart Function in Heart Failure?

Université de Sherbrooke20 enrolled

Overview

Does oral intake of exogenous ketone salt improve heart function measured by cardiac MRI in heart failure compared to oral intake of a carbohydrate placebo?

This study will help to quantify heart and kidney ketone uptake with or without an exogenous ketone salt in heart failure condition. Participants will have 2 different cardiac MRI to perform: 1. Fasting with exogenous ketone salt supplement 2. Fasting with exogenous carbohydrate supplement

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Heart Failure

Interventions

exogenous ketone salt supplementDIETARY_SUPPLEMENT

Dietary Supplement: Fasting water and with exogenous ketone salt supplement. Participants will have to take 1 doses of supplement 30 minutes before the scan.

exogenous carbohydrate supplementDIETARY_SUPPLEMENT

Dietary Supplement: Fasting water and with exogenous carbohydrate supplement. Participants will have to take 1 doses of supplement 30 minutes before the scan.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with heart failure with left ventricle ejection fraction of 40% * Heart failure of ischemic or dilated etiology * Ambulatory patient with a NYHA functional class of II-III; * Stable symptoms and no change in medical therapy in the last month. Exclusion Criteria: * Diabetes * Patients treated with any SGLT2i; * Chronic kidney disease * Acute coronary syndrome in the last 3 months; * Use of parenteral inotropic agents; * Persistent or permanent atrial fibrillation or atrial flutter; * Presence of pacemaker or defibrillator; * Medical condition that causes malabsorption of the test material; * Under ketogenic diet, or using exogenous ketone supplements * Use of nicotinamide adenine dinucleotide (NAD) precursor supplements

Locations (2)

Centre Hospitalier Universitaire de Sherbrooke, departement de cardiologie

Sherbrooke, Quebec, Canada

Centre Hospitalier Universitaire de Sherbrooke, departement de médecine

Sherbrooke, Quebec, Canada

Outcomes

Primary Outcomes

Left ventricle ejection fraction by cardiac MRI under acute intake of exogenous ketone salt compared with exogenous carbohydrate placebo in heart failure patients.

Measure by Cardiac MR in pourcentage between diastolic and systolic volume in millimeter

Time frame: 15 minutes

Secondary Outcomes

Right ventricle ejection fraction by cardiac MRI after intake supplement in heart failure patients.

Measure by Cardiac MR in pourcentage between diastolic and systolic volume in millimeter

Time frame: 15 minutes

Ventricle volume by cardiac MRI after intake supplement in heart failure patients.

Measure by Cardiac MR in millimeter

Time frame: 15 minutes

Cardiac output by cardiac MRI after intake supplement in heart failure patients.

Measure by Cardiac MR in liter per minute

Time frame: 15 minutes

Effects of supplement on serum biomarkers

Concentration of lactate (mmol/L)

Time frame: 60 minutes

Effects of supplement on serum biomarkers

Concentration sodium (mEq/L)

Time frame: 60 minutes

Effects of supplement on serum biomarkers

Concentration of N-terminal pro-B-type natriuretic peptide (NT-proBNP) (pg/ml)

Time frame: 60 minutes

Effects of supplement on serum biomarkers

Data from ClinicalTrials.gov

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