Prizvalve® Transcatheter Valve-in-Valve Implantation Exploratory Study

Inclusion Criteria: 1. Failing bioprosthetic valve (≥moderate stenosis and/or ≥moderate regurgitation); 2. Age≥18 years old who are not in pregnancy or lactation; 3. NYHA Function Class≥ II; 4. Patient who is anatomically suitable for the implantation of the Prizvalve® ; 5. According to heart team , patient is intermediate or above surgical risk or not suitable for redo open heart surgery of valve replacement due to other severe comorbidities ; 6. Heart team agrees valve implantation will likely benefit the patient; 7. Patient understands the purpose of the trial and volunteers to participate in, sign the informed consent form and is willing to accept relevant examinations and clinical follow-ups. Exclusion Criteria: 1. Patients with other valvular diseases that require simultaneous intervention; 2. Patients with other heart diseases that require simultaneous intervention; 3. Estimated life expectancy \< 12 months; 4. Failing valve has moderate and above paravalvular regurgitation; 5. Failing valve in unstable ore not structurally intact; 6. Increased risk of coronary artery obstruction by prosthetic leaflets of the failing valve; 7. Anatomical characteristics that would preclude transcatheter valve implantation; 8. Anatomical characteristics that would increase the risk of left ventricular outflow tract (LVOT) obstruction; 9. Patient with acute myocardial infarction within 30 days; 10. Any therapeutic cardiac operation (excluding previous PCI and pacemaker implantation) is performed within 30 days of the index procedure; 11. Patient with hypertrophic cardiomyopathy with obstruction; 12. Echocardiographic evidence of intracardiac mass, thrombus or vegetation; 13. Patients with active infective endocarditis or other active infections; 14. Patients with severe right ventricular dysfunction, or severe left ventricular dysfunction, left ventricular ejection fraction (LVEF) \< 20%; 15. Patients who cannot tolerate anticoagulant or antiplatelet therapy; 16. Patients with severe untreated coronary artery stenosis requiring revascularization; 17. Patients with cerebrovascular accident within 3 months, excluding transient ischemic attack; 18. Patients who refuse surgical treatment in emergency situations under any circumstances; 19. Patients who have severely disabled Alzheimer's disease and inability to take care of themselves; 20. Patients who have participated in clinical trials of other drugs or medical devices before enrollment and have not yet reached the primary outcome of research; 21. The investigator judged that patient with poor compliance and could not complete the study as required.