Cardiorespiratory Fitness, Apolipoprotein E Genotype, and Cognitive Functions: A Prospective Study

National Taiwan Normal University159 enrolled

Overview

The current research project aims to investigate the interaction of cardiorespiratory fitness (CRF) and the ApoE genotype with neurocognitive functions.

The current research project aims to investigate the interaction of cardiorespiratory fitness (CRF) and the ApoE genotype with neurocognitive functions. The three main purposes of the current research project seek to achieve: 1. An exploration of the associations of, as well as the interactions between, CRF assessed at the Baseline Stage, and the ApoE genotype, along with cognitive functions in cognitively healthy late-middle-aged older adults. 2. The employing of an event-related potential (ERP) to investigate the associations between the baseline CRF, the ApoE genotype, and cognitive functions in cognitively healthy late-middle-aged older adults, as well as the potential underlying neuroelectrical mechanisms. 3. An investigation of the interactions between the changes of CRFs assessed at the Baseline and the Follow-Up Stages and the ApoE genotype in relation to neurocognitive function, as well as the underlying neuroelectrical mechanisms, in cognitively healthy late-middle-aged older adults.

Study Type

OBSERVATIONAL

Enrollment

159

Conditions

Aging Cognitive Change

Interventions

Data collectionsOTHER

Data collections of cognitive function, neuroelectrical activities, ApoE genotype, and physical fitness.

Eligibility

Sex: ALLMin age: 50 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * right handed * no history of cardiorespiratory disease * normal or corrected-to-normal vision based on the 20/20 standard * no risk of performing physical activities, as measured by the Physical Activity Readiness Questionnaire Exclusion Criteria: * the scores of Mini-Mental Status Examination (MMSE) \< 25 and cognitively intact upon study entry * history of psychiatric or neurological diseases * color-blindness

Locations (1)

Department of Physical Education and Sport Sciences, National Taiwan Normal University

Taipei, Taiwan

Outcomes

Primary Outcomes

Changes in Inhibitory Performance: Stroop Task

Inhibitory performance was assessed using the computerized Stroop task at the Baseline and at the Follow-Up assessments. The difference in response time (RT) between the Baseline and the Follow-Up Stages was calculated as the index of the inhibitory performance.

Time frame: 30 minutes each at the Baseline and the Follow-Up visit at Month 18

Changes in Neuroelectrical Activities

The neuroelectrical activities (P3 component) during the Stroop task were recorded and analyzed using the Neuroscan system. The difference in P3 amplitudes of incongruent trials between the Baseline and the Follow-Up Stages was calculated as the index of the neuroelectrical index.

Time frame: 30 minutes each at the Baseline and the Follow-Up visit at Month 18

Secondary Outcomes

Number of Participants for Whom ApoE Genotype Was Determined

Participants' ApoE genotype was determined based on the genetic biomarkers (rs429358 and rs7412)

Time frame: 5 minutes at the Baseline Stage.

Physical Fitness Measurements: Changes in Aerobic Fitness

Participants' aerobic fitness was estimated using the submaximal cycle ergometer test at the baseline and at the follow-up assessments. The difference in maximum oxygen consumption (VO2 max) between the Baseline and the Follow-Up Stages was calculated as the index of aerobic fitness.

Time frame: 30 minutes each at the Baseline and the Follow-Up visit at Month 18

Data from ClinicalTrials.gov

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