Present study aims to track the post-stroke cognitive trajectories and to investigate its inter-individual variability.
The study aim is to establish a model capturing patients' inter-individual variability in susceptibility to stroke damage to predict stroke-induced cognitive trajectories. This is a prospective longitudinal observational national monocentric study for 6 years (recruitment during the first 3 years). The investigators perform comprehensive neuropsychological testing in i) acute stroke phase (0-10 days post-stroke), ii) sub-acute stroke phase (3 months post-stroke), and iii) chronic stroke phase (12 months and 3 years post-stroke). At each time point, cognitive performances as well as clinical and functional status will be assessed. Furthermore, the investigators will assess the proxies of cognitive reserve and the level of post-stroke physical activity.
Study Type
OBSERVATIONAL
Enrollment
335
Department of Neurology, Inselspital, University Hospital Bern, University of Bern
Bern, Switzerland
Number of participants with delayed cognitive deterioration (DCD)
The investigators will assess number of participants with deterioration of the cognitive performance in ≥2 cognitive domains on ≥ 1 Standard Deviation (1 SD).
Time frame: at 3 months, at 12 months and at 36 months post-stroke
Number of participants with delayed functional deterioration
The investigators will assess number of participants with deterioration of functional disability will be defined as decrease in disability level to one point assessed via modified Rankin Scale (mRS, 0-6, whereas 0=no functional disability).
Time frame: at 3 months, at 12 months and at 36 months post-stroke
Number of participants with post-stroke cognitive impairment
The investigators will assess number of participants with post-stroke cognitive impairment that is defined as at least moderate deficit (performance below -1.5 SD) in ≥ 2 cognitive domains. The cognitive performance across all basic cognitive domains is assessed using a standardized neuropsychological test battery with available normative data. The test battery includes tests from Consortium to Establish a Registry for Alzheimer's Disease (CERAD), Trail Making Test A + B, verbal fluency, alertness test, digit span (forward and backward), Bells test, and Montreal Cognitive Assessment.
Time frame: 10 days post-stroke, 3 months, 12 months and at 36 months post-stroke
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