Prognostic Value of the AMR Measured After PPCI in STEMI Patients

N/AActive Not RecruitingNCT05653765

Henan Institute of Cardiovascular Epidemiology2,663 enrolled

Overview

The goal of this observational study is to learn about in STEMI with Primary PCI Patients. The main questions it aims to answer are: * To determine the value of AMR in predicting the long-term clinical prognosis of patients with STEMI after PPCI, and to find the best cut-off value. * Analyze the factors of PPCI affecting AMR and explore the effective measures of PPCI microcirculation protection. Radiographic images of STEMI receiving primary PCI treatment in several chest pain centers in China will be included. The last image of the infarct-related vessel will be used as a target to calculate its AMR. The relationship between AMR and long-term clinical prognosis was analyzed.

Study Type

OBSERVATIONAL

Enrollment

2,663

Conditions

Coronary Heart Disease ST Elevation Myocardial Infarction

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Aged 18 or older * Type 1 myocardial infarction * Receive PPCI Exclusion Criteria: * Failed to identify culprit vessels. * Structural heart disease with moderate to severe aortic valve or mitral regurgitation and or stenosis that may affect cardiac function * Dialysis patients with severe renal insufficiency * Severe and uncontrollable arrhythmia * Complicated with dilated cardiomyopathy * Unable to tolerate dual antiplatelet therapy * Severe and uncontrollable anemia * Hyperthyroidism * TIMI blood flow 0-1 grade after PPCI

Locations (5)

Shangqiu first people's Hospital

Shangqiu, Henan, China

Department of Cardiology, First Affiliated Hospital of Xinxiang Medical University

Xinxiang, Henan, China

Yongcheng Central Hospital

Yongcheng, Henan, China

Fuwai central China cardiovascular Hospital

Zhengzhou, Henan, China

Renji Hospital, School of Medicine, Shanghai Jiao Tong University,

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

MACEs

cardiac death, hospitalization for heart failure, target vessel revascularization，non-fatal MI

Time frame: 12 months

Secondary Outcomes

cardiac death

All cause deaths will be considered cardiac unless a definite noncardiac cause can be established.

Time frame: 12 months

hospitalization for heart failure

Hospitalization for heart failure was defined as admission because of new or deteriorating signs and symptoms of heart failure combined with the findings of noninvasive imaging or elevated B-type natriuretic peptide(BNP) and/or N-terminal pro-BNP concentration, and a discharge diagnosis of congestive heart failure.

Time frame: 12 months

target lesion revascularization

The following 3 conditions need to be met at the same time: 1. The new stenosis that developed within previously treated coronary segments and within 5 mm of their borders; 2. The new stenosis resulted in the vessel μQFR ≤ 0.80; 3. The patient subsequently underwent repeat PCI or coronary artery bypass grafting (CABG).

Time frame: 12 months

Repeated myocardial infarction

Time frame: 12 months