Perioperative multimodal analgesia, defined by the use of various analgesic medications targeting different drug receptors, provides adequate pain relief with minimal or no opiate consumption. Therefore, it represents one of the cornerstone of Enhanced Recovery After Surgery (ERAS) protocols, as the reduction in opioid use and the associated side effects may eventually reduce length of hospital stay, increase patient satisfaction and minimise the risk of long-term opioid use. Regional and neuraxial anesthesia techniques are key interventions to provide successful analgesia in the context of a multimodal strategy. Intrathecal morphine, for its effectiveness and potential of reducing the need of intravenous postoperative opioids, seems an attractive option in the case of hysterectomy, one of the most common major surgical procedures performed in women, associated with severe postoperative pain even when performed laparoscopically. The aim of our observational retrospective study is therefore to compare the analgesic efficacy and the safety of morphine administered by intrathecal route versus intravenous route during the first 48 hours after performance of laparoscopic/laparotomic hysterectomy.
Study Type
OBSERVATIONAL
Enrollment
670
Lumbar puncture was performed before the induction of general anesthesia, in the operating room. Spinal anesthesia was performed in sitting position using a midline approach into the L3-L4 or L4-L5 interspaces with a 25ga pencil-point spinal needle administering 75-100 mcg morphine, with or without local anesthetic (levobupivacaine 0,5% 10-15 mg or bupivacaine 0,5% 10-15 mg or ropivacaine 0,5% 10-15 mg), depending on the anesthesiologist's preference. General anesthesia was then conducted according to clinical practice. All patients were transferred in the Post-Anesthesia Care Unit (PACU) at the end of surgery. Throughout the first 48 postoperative hours, all patients were regularly evaluated in the hospital ward by a member of the Acute Pain Service Team.
General anesthesia was conducted according to clinical practice and a morphine bolus was administered before emergence from anesthesia according to clinical needs. All patients were then transferred in the Post-Anesthesia Care Unit (PACU) at the end of surgery and received Patient-Controlled Analgesia (PCA) with morphine 1mg/mL (CADD®-Solis 2110 Infusion System, Smiths Medical ASD, Inc., USA, 1 mL bolus on demand, no background infusion, 7 minute lockout, max 8 mg/h). Throughout the first 48 postoperative hours, all patients were regularly evaluated in the hospital ward by a member of the Acute Pain Service Team.
Catarci Stefano
Roma, Italy
Numeric pain rating scale (NPRS)
Numeric pain rating scale (NPRS) (ranging from 0, "no pain" and 10, "the worst pain imaginable") at rest
Time frame: Time 0 (= baseline, i.e. at the time of Postoperative Anesthesia Care Unit arrival)
Numeric pain rating scale (NPRS)
Numeric pain rating scale (NPRS) (ranging from 0, "no pain" and 10, "the worst pain imaginable") at rest
Time frame: 6 hours from baseline
Numeric pain rating scale (NPRS)
Numeric pain rating scale (NPRS) (ranging from 0, "no pain" and 10, "the worst pain imaginable") at rest
Time frame: 12 hours from baseline
Numeric pain rating scale (NPRS)
Numeric pain rating scale (NPRS) (ranging from 0, "no pain" and 10, "the worst pain imaginable") at rest
Time frame: 24 hours from baseline
Numeric pain rating scale (NPRS)
Numeric pain rating scale (NPRS) (ranging from 0, "no pain" and 10, "the worst pain imaginable") at rest
Time frame: 48 hours from baseline
Adverse events
Any adverse event, like sedation, itching, nausea, motor weakness, signs of local anesthetic toxicity
Time frame: After the end of surgery, in the first 48 postoperative hours
Constipation
The presence of opioid-induced constipation
Time frame: After the end of surgery, in the first 48 postoperative hours
Mobilization
Time of first mobilization after the surgical procedure
Time frame: After the end of surgery, in the first 48 postoperative hours
Intraoperative opioid consumption
Total opioid consumption
Time frame: During the surgery
Postoperative opioid consumption
Total opioid consumption
Time frame: After the end of surgery, in the first 48 postoperative hours
Rescue analgesia
The use of non-opioid rescue analgesics in case of NPRS \> 3, other than around the clock pain medications
Time frame: After the end of surgery, in the first 48 postoperative hours
Length of PACU stay
Length of stay in Postoperative Anesthesia Care Unit (PACU)
Time frame: Time from admission to dismissal from PACU, an average of 1 hour
Length of hospital stay
The Length of Hospital Stay (LOS) after the surgery
Time frame: Time from dismissal from PACU to dismissal from hospital, an average of 72 hours
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