New York City Observational Study of Mpox Immunity

Inclusion Criteria: 1. Must be able to understand and sign the Informed Consent Form (ICF) 2. ≥18 years of age a. Including breastfeeding and pregnant people 3. Must have one or the other of criteria a and b, or can have both: 1. Planning receipt of (in the next 30 days) or have received the mpox vaccine, and/or 2. people with recent mpox infection who are out of isolation (≥30 days after symptom onset) 4. Willingness and ability to participate in all study procedures Exclusion Criteria: 1. Known clinically significant anemia (i.e., Hb \< 10 g/dL) 2. Contraindication to phlebotomy based on investigator judgement; e.g., anti-coagulation therapy with history of phlebotomy complications, or clinically significant thrombocytopenia 3. Any condition that, in the opinion of the Investigator, would make study participation unsafe for the individual or would interfere with the objectives of the study