Rescue Thrombolysis for Medium Vessel Occlusion (RESCUE-TNK)

Inclusion Criteria: 1. Age ≥18 years; 2. Medium vessel occlusion (MeVO), referring to M2-3 of MCA; A1-3 of ACA; P1-3 of PCA; PICA, AICA or SCA (including primary, distal embolism in the same region after thrombectomy or concurrent embolism in other regions). * Primary MeVO as detected by the first DSA examination or secondary MeVO after mechanical thrombectomy for large vessel occlusion; * MeVO causes neurological deficits in motor strength, language, vision etc; * Endovascular mechanical thrombectomy cannot be performed as assessed by the investigator; * Absence of parenchymal hematoma on CT images performed in the angio suite. 3. Within 24 hours from symptom onset; 4. Signed informed consent by patient or patient's legally authorized representative. Exclusion Criteria: 1. Patients with completed infarction in the territory of the MeVO on non-contrast CT; 2. Patients with intracranial hemorrhage; 3. Coagulation disorders, tendency for systemic hemorrhagic, thrombocytopenia (\<100,000/mm3); 4. Severe hepatic or renal dysfunction, increase in ALT or AST (more than 2 times of upper limit of normal value), increase in serum creatinine (more than 1.5 times of upper limit of normal value) or requiring dialysis; 5. After mechanical thrombectomy, severe and sustained (\> 5 minutes) uncontrolled hypertension (systolic blood pressure over 180mmHg or diastolic blood pressure over 105 mmHg); 6. Patients with contraindication or allergy to any ingredient of study medication; 7. Pregnancy, plan to get pregnant or active lactation; 8. The estimated life expectancy is less than 6 months due to other serious diseases; 9. Other conditions unsuitable for this clinical study as assessed by researcher.