Dose Optimization of Rivaroxaban Combined With Rifampicin

Inclusion Criteria: * Patients aged\>18 years * The diagnosis was periprosthetic infection after joint replacement * Orthopedic operations such as revision of artificial joints, removal of prostheses, debridement, etc. for the treatment of periprosthetic infection * Rivaroxaban was used to prevent deep vein thrombosis after operation. Exclusion Criteria: * Patients allergic to any excipient in rivaroxaban, rifampicin or tablets * Patients with clinically significant active bleeding * Patients with significant risk of bleeding * Patients with liver disease with coagulation abnormalities and clinical-related bleeding risk, including patients with cirrhosis who reached Child Pugh C grade * Pregnant women and breastfeeding women * Patients taking combined drugs affecting rivaroxaban metabolism * Patients who were unable or unwilling to cooperate with the study (Such as mental or memory disorders) * Patients discontinued without meeting study target days * Patients with severe renal insufficiency (creatinine clearance rate \< 30ml / min)