Comparison of Two Stapled Antimesenteric Anastomosis for CD: a Randomized Control Trial Study

Jinling Hospital, China236 enrolled

Overview

The postoperative recurrence of Crohn's diseases (CD) remains high. Stapled anti-mesenteric functional end-to-end anastomosis was safe for CD patients. Its impact on the postoperative recurrence of CD was unknown. Whether it is superior than the conventional anastomosis (stapled antimesenteric isoperistaltic side-to-side anastomosis) needs explored. The trial aims to compare the different impacts of the two antimesenteric anastomosis configurations on the anastomotic recurrence following bowel resection.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

236

Conditions

Crohn Disease Recurrence

Interventions

patients in this arm will receive stapled Kono-S anastomosis after bowel resection

Side-to-side groupPROCEDURE

patients in this arm will receive stapled antimesenteric isoperistaltic side-to-side anastomosis after bowel resection

Eligibility

Sex: ALLMin age: 16 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients with Crohn's disease needing bowel resection and anastomosis; * ileocolic anastomosis； * written consent acquired Exclusion Criteria: * patients underwent enterostomy; * small bowel anastomosis; * anticipating other trial.

Locations (1)

Department of General Surgery, Jinling hosptal,Medical School of Nanjing University

Nanjing, Jiangsu, China

RECRUITING

Outcomes

Primary Outcomes

the endoscopic recurrence rate at 1 year after surgery

Time frame: at 1 year after surgery(6-18month)