The aim of this study is to investigate the effect of high-intensity interval training and moderate intensity continuous training on cardiopulmonary functions in chronic heart failure.
enroll chronic heart failure patients into 3 randomized controlled group * high intensity interval training * moderate intensity continous training * control perform cardica rehab for 12 weeks, compare primary and secondary endpoints between baseline and 12 weeks results
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
60
aerobic exercise on a treadmill (T7M, Motus, Paju, South Korea) accompanied by an electrocardiogram monitoring device (Q-Tel Rehabilitation Management System, Mortara Inc., Milwaukee, WI, USA) and a blood pressure monitor
Inha University hospital
Incheon, Gyeonggi-do, South Korea
RECRUITINGMaximal or peak oxygen consumption (VO2max or VO2peak, same meaning) (kg/ml/min)
at the end of training, from baseline to 12 weeks
Time frame: compare baseline data with 12 weeks rehabilitation data
Anaerobic threshold (kg/ml/min)
The anaerobic threshold is the highest exercise intensity that you can sustain for a prolonged period without lactate substantially building up in your blood.
Time frame: compare baseline data with 12 weeks rehabilitation data
6minute walk test (meter)
Time frame: compare baseline data with 12 weeks rehabilitation data
maximal heart rate (bpm)
Time frame: compare baseline data with 12 weeks rehabilitation data
systolic blood pressure (mmHg)
Time frame: compare baseline data with 12 weeks rehabilitation data
diastolic blood pressure (mmHg)
Time frame: compare baseline data with 12 weeks rehabilitation data
resting heart rate (bpm)
Time frame: compare baseline data with 12 weeks rehabilitation data
diastolic blood presure (mmHg)
Time frame: compare baseline data with 12 weeks rehabilitation data
depression scale by Patient Health Questionnaire
Patient Health Questionnaire (PHQ; range, 0-27; higher score = severe depression; cut-off score of 5 for minimal depression)
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Time frame: compare baseline data with 12 weeks rehabilitation data
anxiety scale by Generalized Anxiety Disorder Scale
Generalized Anxiety Disorder Scale (GAD; range, 0-21; higher score = severe anxiety; cut-off score of 5 for mild anxiety)
Time frame: compare baseline data with 12 weeks rehabilitation data
fatigue scale by fatigue severity scale
fatigue severity scale (FSS; range, 9-63; higher score = severe fatigue; cut-off score of 4 for fatigue)
Time frame: compare baseline data with 12 weeks rehabilitation data
Quality of Life (QoL) questionnaire (MacNew)
MacNew QoL questionnaire is a measurement tool for patients with cardiac disease that measures physical, emotional, and social functional levels to provide overall QoL.
Time frame: compare baseline data with 12 weeks rehabilitation data