Postoperative Pain After Caesarian Section

Conrad Arnfinn Bjørshol108 enrolled

Overview

To examine if perioperative pain/nausea/pruritus is altered when current standard analgesia for caesarian section (CS) is replaced with new guideline recommended analgesia.

Control group (current analgesia, elective CS) is compared to current analgesia for emergency CS, and guideline recommended analgesia. Current analgesia for CS: Spinal hyperbaric bupivacaine 5 mg/ml, 9-11 mg. Spinal fentanyl 10-15 ug. Postoperative: Paracetamol 1g x 4, ibuprofen 400 mg x 4 po, oxycodone 10 mg (\<70 kg) or 20 mg (\>70 kg) x 2 po, additional oxycodone 2,5 mg iv/5 mg po when needed. Guideline recommended analgesia for CS: Spinal hyperbaric bupivacaine 5 mg/ml, 9-11 mg. Spinal fentanyl 12,5 ug. Spinal morphine 0,05 mg. After delivery of baby: Dexamethasone 8 mg iv, paracetamol 1g iv, parecoxib 40 mg iv. Postoperative: Paracetamol 1g x 4, ibuprofen 600 mg x 4 po, oxycodone 2,5 mg iv/5 mg po when needed.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

108

Conditions

Pain, Postoperative Pruritus Nausea and Vomiting Following Administration of Anaesthetic Agent Consumption

Interventions

Bupivacaine-fentanyl-morphine elective groupDRUG

Guideline recommended analgesia in elective caesarian section.

Bupivacaine-fentanyl elective groupDRUG

Current analgesia in elective caesarian section.

Bupivacaine-fentanyl emergency groupDRUG

Current analgesia in emergency caesarian section.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: \- Healthy parturient, term pregnancy, undergoing caesarian section Exclusion Criteria: * Patient refusal * Maternal heart or lung disease (not including mild asthma) * Known or suspected obstructive sleep apnoea syndrome * Pre-eclampsia * Body mass index \> 40 * Indulin-dependent diabetes mellitus * Contraindications to ibuprofen, dexamethasone or morphine * Chronic pain * Neurological disease * Drug abuse * Age \< 18 years * American Society of Anesthesiologists (ASA) 3 * Patients receiving other forms of anaesthesia (epidural or general)

Locations (1)

Stavanger University Hospital

Stavanger, Rogaland, Norway