Comparison of Triamcinolone With Pentoxifylline and Vitamin- E Efficacy in the Treatment of Stage 2 and 3 Oral Submucous Fibrosis

Altamash Institute of Dental Medicine40 enrolled

Overview

To compare the efficacy of Triamcinolone with Pentoxifylline and Vitamin E in patients with stage two and three oral submucous fibrosis.

To compare the efficacy of Triamcinolone with Pentoxifylline and Vitamin E in patients with stage two and three oral submucous fibrosis. It was a randomized control clinical trial to compare efficacy of injection steroids versus pentoxifylline and vitamin E in the treatment of stage 2 and 3 OSF patient. Total 40 patients who presented with signs and symptoms of OSF were enrolled in our study that was evaluated over the period of (January 2020 to September 2021). Parameters taken in the study were age and mouth opening. Descriptive statistics and paired t-test were used for statistical analysis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Triamcinolone Pentoxifylline Vitamin E Oral Submucosa Fibrosis Tumor

Interventions

TriamcinoloneDRUG

Comparison of Triamcinolone with Pentoxifylline and Vitamin- E Efficacy

Pentoxifylline with Vitamin EDRUG

Comparison of Triamcinolone with Pentoxifylline and Vitamin- E Efficacy

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with clinically diagnosed OSMF who have not undergone any treatment of OSMF in past * Patients willing to quit their tobacco chewing habit, gutkha areca nut smoking * Patients who are ready to attend regular follow-ups Exclusion Criteria: * Patients who have undergone any treatment for OSF in past * Patients with any evidence of cardiac, gastrointestinal, kidney, metabolic disorders, pregnant and lactating women's * Patients with any co-existing disorder of the orofacial region other than OSF which may interfere with the study protocol

Locations (1)

Altamash Institute of Dental Medicine

Karachi, Sindh, Pakistan

Outcomes

Primary Outcomes

Group 1: Triamcinolone measuring mouth opening using calibrated Vernier Caliper

Measuring mouth opening measuring mouth opening using calibrated Vernier Caliper by recording in millimeters the maximum mouth opening

Time frame: 21 months

Group 2: Pentoxifylline with Vitamin E measuring mouth opening using calibrated Vernier Caliper

Measuring mouth opening measuring mouth opening using calibrated Vernier Caliper by recording in millimeters the maximum mouth opening

Time frame: 21 months

Data from ClinicalTrials.gov

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