Effect of General Anesthesia Method on Cardiac Risk Patients on Ischemia Modified Markers

Ataturk University70 enrolled

Overview

To examine the effects of the general anesthesia method chosen in non-cardiac surgical operations of patients with cardiac risk on the levels of cardiac markers

To examine the effects of the general anesthesia method chosen in non-cardiac surgical operations of patients with cardiac risk on the levels of cardiac markers like; serum levels of the Creatine Kinase, Creatine Kinase Myocardial Band, high sensitive troponin, heart-type fatty acid-binding protein, ischemia-modified albumin and albumin. And evaluate the effect of anesthesia method on haemodynamic.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SCREENING

Masking

NONE

Enrollment

Conditions

Anesthesia

Interventions

TIVAPROCEDURE

Anesthesia will be maintained with propofol (6-10 mg/kg/hour) and remifentanil (0.1-0.3 μg/kg/min).

GENERAL ANESTHESIAPROCEDURE

Anesthesia will be maintained with sevoflurane (2 ml/min) 50% oxygen and remifentanil (0.1-0.3 μg/kg/min).

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Being 18 years or older * Getting a score of 2 and above according to the Lee cardiac index * Having a non-cardiac surgical procedure that will take at least three hours * ASA II or III Exclusion Criteria: * Under 18 years old * Those who refused to participate in the study * Patients with chronic renal failure * Patients with creatinine value ≥ 1.5 mg/dl * Surgery that takes less than 3 hours * Patients with liver failure * Refusing to participate in the study * Being allergic to the drugs used

Outcomes

Primary Outcomes

comparing serum levels of ischemia modified albumin

serum levels of ischemia modified albumin (in terms of IU/ML)

Time frame: intraoperative period

comparing serum levels of heart fatty acid binding protein

serum levels of heart fatty acid binding protein (in terms of mcg/L)

Time frame: intraoperative period

Secondary Outcomes

The effect of anesthesia method used in cardiac risk patients in terms of ephedrine consumption

used ephedrine amount (mg)

Time frame: intraoperative period

Central Contacts

Ayşenur Dostbil

CONTACT

+905333677796 adostbil@hotmail.com

Canan Atalay

CONTACT

+905333635318 cananatalay@hotmail.com

Data from ClinicalTrials.gov

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